Chronic progressive renal disease: rate of change of serum creatinine concentration

W. E. Rutherford; J. Blondin; J. P. Miller; A. S. Greenwalt; J. D. Vavra

doi:10.1038/ki.1977.8

Chronic progressive renal disease: rate of change of serum creatinine concentration

W. E. Rutherford, J. Blondin, J. P. Miller, A. S. Greenwalt, J. D. Vavra

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Abstract

The rate of change of the serum creatinine concentration in 63 patients with chronic progressive renal disease of varied etiology was examined by linear regression analysis using the logarithm or the reciprocal of the serum creatinine concentration versus time. A single straight line was described by one or the other of these relationships in 53 patients. Six patients had an accelerated rate of nephron destruction terminally (two slopes) regardless of the mathematical analysis. The remaining four patients had course changes either due to apparent spontaneous remissions or temporally related to therapy. These data suggest that (functional) nephron loss in chronic progress disease is orderly and mathematically definable. The theoretical implications are that functional nephron loss is either exponential (log Cr) or constant (1/Cr).

Original language	English
Pages (from-to)	62-70
Number of pages	9
Journal	Unknown Journal
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/ki.1977.8
State	Published - 1977

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title = "Chronic progressive renal disease: rate of change of serum creatinine concentration",

abstract = "The rate of change of the serum creatinine concentration in 63 patients with chronic progressive renal disease of varied etiology was examined by linear regression analysis using the logarithm or the reciprocal of the serum creatinine concentration versus time. A single straight line was described by one or the other of these relationships in 53 patients. Six patients had an accelerated rate of nephron destruction terminally (two slopes) regardless of the mathematical analysis. The remaining four patients had course changes either due to apparent spontaneous remissions or temporally related to therapy. These data suggest that (functional) nephron loss in chronic progress disease is orderly and mathematically definable. The theoretical implications are that functional nephron loss is either exponential (log Cr) or constant (1/Cr).",

author = "Rutherford, {W. E.} and J. Blondin and Miller, {J. P.} and Greenwalt, {A. S.} and Vavra, {J. D.}",

note = "Funding Information: This work was supported by National Institutes of Health, Division of Research Sources, grant RR 00036, and Public Health Service grant AM 09976. The authors acknowledge the help of Dr. John Kis- sane who reviewed all biopsy material. Miss Patti",

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T1 - Chronic progressive renal disease

T2 - rate of change of serum creatinine concentration

AU - Rutherford, W. E.

AU - Blondin, J.

AU - Miller, J. P.

AU - Greenwalt, A. S.

AU - Vavra, J. D.

N1 - Funding Information: This work was supported by National Institutes of Health, Division of Research Sources, grant RR 00036, and Public Health Service grant AM 09976. The authors acknowledge the help of Dr. John Kis- sane who reviewed all biopsy material. Miss Patti

PY - 1977

Y1 - 1977

N2 - The rate of change of the serum creatinine concentration in 63 patients with chronic progressive renal disease of varied etiology was examined by linear regression analysis using the logarithm or the reciprocal of the serum creatinine concentration versus time. A single straight line was described by one or the other of these relationships in 53 patients. Six patients had an accelerated rate of nephron destruction terminally (two slopes) regardless of the mathematical analysis. The remaining four patients had course changes either due to apparent spontaneous remissions or temporally related to therapy. These data suggest that (functional) nephron loss in chronic progress disease is orderly and mathematically definable. The theoretical implications are that functional nephron loss is either exponential (log Cr) or constant (1/Cr).

AB - The rate of change of the serum creatinine concentration in 63 patients with chronic progressive renal disease of varied etiology was examined by linear regression analysis using the logarithm or the reciprocal of the serum creatinine concentration versus time. A single straight line was described by one or the other of these relationships in 53 patients. Six patients had an accelerated rate of nephron destruction terminally (two slopes) regardless of the mathematical analysis. The remaining four patients had course changes either due to apparent spontaneous remissions or temporally related to therapy. These data suggest that (functional) nephron loss in chronic progress disease is orderly and mathematically definable. The theoretical implications are that functional nephron loss is either exponential (log Cr) or constant (1/Cr).

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Chronic progressive renal disease: rate of change of serum creatinine concentration

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