Chronic progressive external ophthalmoplegia in the absence of ptosis

Robert C. Bucelli, Michael S. Lee, Collin M. McClelland

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Classically defined as bilateral, symmetric, and progressive ophthalmoparesis with myopathic ptosis, chronic progressive external ophthalmoplegia (CPEO) rarely has been reported in the absence of ptosis. We describe 2 patients with CPEO and without ptosis who presented with binocular diplopia related to small-angle esodeviations, poor fusional amplitudes, and slow saccades. In both cases, hematological studies and neuroimaging ruled out alternative etiologies, whereas muscle biopsy showed findings of mitochondrial myopathy.

Original languageEnglish
Pages (from-to)270-274
Number of pages5
JournalJournal of Neuro-Ophthalmology
Issue number3
StatePublished - Aug 23 2016


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