TY - JOUR
T1 - Chronic Lung Allograft Dysfunction
T2 - Clinical Manifestations and Immunologic Mechanisms
AU - Bery, Amit I.
AU - Belousova, Natalia
AU - Hachem, Ramsey
AU - Roux, Antoine
AU - Kreisel, Daniel
N1 - Publisher Copyright:
Copyright © 2024 Wolters Kluwer Health, Inc.
PY - 2024
Y1 - 2024
N2 - The term “chronic lung allograft dysfunction” has emerged to describe the clinical syndrome of progressive, largely irreversible dysfunction of pulmonary allografts. This umbrella term comprises 2 major clinical phenotypes: bronchiolitis obliterans syndrome and restrictive allograft syndrome. Here, we discuss the clinical manifestations, diagnostic challenges, and potential therapeutic avenues to address this major barrier to improved long-term outcomes. In addition, we review the immunologic mechanisms thought to propagate each phenotype of chronic lung allograft dysfunction, discuss the various models used to study this process, describe potential therapeutic targets, and identify key unknowns that must be evaluated by future research strategies.
AB - The term “chronic lung allograft dysfunction” has emerged to describe the clinical syndrome of progressive, largely irreversible dysfunction of pulmonary allografts. This umbrella term comprises 2 major clinical phenotypes: bronchiolitis obliterans syndrome and restrictive allograft syndrome. Here, we discuss the clinical manifestations, diagnostic challenges, and potential therapeutic avenues to address this major barrier to improved long-term outcomes. In addition, we review the immunologic mechanisms thought to propagate each phenotype of chronic lung allograft dysfunction, discuss the various models used to study this process, describe potential therapeutic targets, and identify key unknowns that must be evaluated by future research strategies.
UR - http://www.scopus.com/inward/record.url?scp=85200776001&partnerID=8YFLogxK
U2 - 10.1097/TP.0000000000005162
DO - 10.1097/TP.0000000000005162
M3 - Review article
C2 - 39104003
AN - SCOPUS:85200776001
SN - 0041-1337
JO - Transplantation
JF - Transplantation
M1 - 10.1097/TP.0000000000005162
ER -