Chronic Liver Disease Patients have Worse Outcomes and Increased Postoperative Complications after Orthopedic Fractures

Marianna G. Mavilia, Richa Bhardwaj, Dorothy Wakefield, Raffi Karagozian

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Introduction:Cirrhotic patients are at a higher risk for sustaining orthopedic fractures with a reported prevalence of 5% to 20%. Cirrhosis also affects wound healing and bleeding risk, and hence, impacts the postoperative outcomes after fracture repair. However, there is limited data available on the postoperative risk factors and clinical outcomes of fractures in patients with chronic liver disease (CLD).Methods:Data from the National Inpatient Sample for the years 2012 to 2015 were analyzed. Patients were identified using ICD-9 codes for any fracture. ICD-9 codes for CLD were used to categorize patients into CLD and non-CLD groups. Primary outcomes included inpatient mortality, length of stay (LOS), and total hospital charges. Secondary outcomes included complications such as postoperative infection, prosthetic failure, bleeding, and improper wound healing.Results:A total of 931,193 patient encounters for orthopedic fractures were identified and divided into 17,388 with CLD and 913,806 without CLD (non-CLD). The inpatient mortality in patients with CLD was almost twice that of non-CLD patients (odds ratio, 1.95; 95% confidence interval, 1.8-2.1). Patients with CLD also had a longer mean LOS at 7.4±8.6 days versus 5.6±7.2 days (P<0.001) and higher total hospital charges at $76,198±99,494 versus $64,294±95,673 (P<0.001). CLD patients also had higher rates of infections, improper wound healing, and bleeding.Discussion:In this large retrospective study, CLD patients with fractures had significantly higher mortality, LOS and hospital charges. These findings correlate with the higher rates of infection, bleeding, and poorer wound healing in this population. Increased clinician awareness of these risks is a key to improving the care of CLD patients.

Original languageEnglish
Pages (from-to)E371-E375
JournalJournal of Clinical Gastroenterology
Issue number9
StatePublished - Oct 1 2019


  • cirrhosis
  • orthopedic surgery
  • outcomes


Dive into the research topics of 'Chronic Liver Disease Patients have Worse Outcomes and Increased Postoperative Complications after Orthopedic Fractures'. Together they form a unique fingerprint.

Cite this