@article{e5a3e9def0d945059dc883c1ca998793,
title = "Chronic intraventricular infusion of glial cell line-derived neurotrophic factor (GDNF) rescues some cerebellar purkinje cells from heredodegeneration",
abstract = "Cerebellar Purkinje cells degenerate in shaker mutant rats. Glia cell line-derived neurotrophic factor (GDNF) was chronically infused intraventricularly in an attempt to rescue mutant Purkinje cells from dying. Four weeks of chronic GDNF infusion delayed the degeneration of many but not all Purkinje cells. Surviving Purkinje cells formed spatially related groups interrupted by other groups of degenerated Purkinje cells. There was a positive correlation in GDNF-supported Purkinje cell survival and persistence of normal motor behaviors.",
author = "Tolbert, {Daniel L.} and Bradley, {Matthew W.} and Tolod, {Emeline G.} and Ignacio Torres-Aleman and Clark, {B. Ruth}",
note = "Funding Information: Note. Purkinje cell survival was supported by chronic GDNF infusion in shaker mutant rats. Values represent the number of surviving Purkinje cells per unit length (1 cm) of cortex in representative midline cerebellar sections from normal, control, and GDNF-infused mutants. C–F are values from the indicated sections illustrated in Fig. 1.",
year = "2001",
doi = "10.1006/exnr.2001.7718",
language = "English",
volume = "170",
pages = "375--379",
journal = "Experimental Neurology",
issn = "0014-4886",
number = "2",
}