TY - JOUR
T1 - Chronic inflammatory lesions of the placenta are associated with an up-regulation of amniotic fluid CXCR3
T2 - A marker of allograft rejection
AU - Maymon, Eli
AU - Romero, Roberto
AU - Bhatti, Gaurav
AU - Chaemsaithong, Piya
AU - Gomez-Lopez, Nardhy
AU - Panaitescu, Bogdan
AU - Chaiyasit, Noppadol
AU - Pacora, Percy
AU - Dong, Zhong
AU - Hassan, Sonia S.
AU - Erez, Offer
N1 - Publisher Copyright:
© 2018 Walter de Gruyter GmbH, Berlin/Boston.
PY - 2018/2/23
Y1 - 2018/2/23
N2 - Objective: The objective of this study is to determine whether the amniotic fluid (AF) concentration of soluble CXCR3 and its ligands CXCL9 and CXCL10 changes in patients whose placentas show evidence of chronic chorioamnionitis or other placental lesions consistent with maternal anti-fetal rejection. Methods: This retrospective case-control study included 425 women with (1) preterm delivery (n=92); (2) term in labor (n=68); and (3) term not in labor (n=265). Amniotic fluid CXCR3, CXCL9 and CXCL10 concentrations were determined by ELISA. Results: (1) Amniotic fluid concentrations of CXCR3 and its ligands CXCL9 and CXCL10 are higher in patients with preterm labor and maternal anti-fetal rejection lesions than in those without these lesions [CXCR3: preterm labor and delivery with maternal anti-fetal rejection placental lesions (median, 17.24 ng/mL; IQR, 6.79-26.68) vs. preterm labor and delivery without these placental lesions (median 8.79 ng/mL; IQR, 4.98-14.7; P=0.028)]; (2) patients with preterm labor and chronic chorioamnionitis had higher AF concentrations of CXCL9 and CXCL10, but not CXCR3, than those without this lesion [CXCR3: preterm labor with chronic chorioamnionitis (median, 17.02 ng/mL; IQR, 5.57-26.68) vs. preterm labor without chronic chorioamnionitis (median, 10.37 ng/mL; IQR 5.01-17.81; P=0.283)]; (3) patients with preterm labor had a significantly higher AF concentration of CXCR3 than those in labor at term regardless of the presence or absence of placental lesions. Conclusion: Our findings support a role for maternal anti-fetal rejection in a subset of patients with preterm labor.
AB - Objective: The objective of this study is to determine whether the amniotic fluid (AF) concentration of soluble CXCR3 and its ligands CXCL9 and CXCL10 changes in patients whose placentas show evidence of chronic chorioamnionitis or other placental lesions consistent with maternal anti-fetal rejection. Methods: This retrospective case-control study included 425 women with (1) preterm delivery (n=92); (2) term in labor (n=68); and (3) term not in labor (n=265). Amniotic fluid CXCR3, CXCL9 and CXCL10 concentrations were determined by ELISA. Results: (1) Amniotic fluid concentrations of CXCR3 and its ligands CXCL9 and CXCL10 are higher in patients with preterm labor and maternal anti-fetal rejection lesions than in those without these lesions [CXCR3: preterm labor and delivery with maternal anti-fetal rejection placental lesions (median, 17.24 ng/mL; IQR, 6.79-26.68) vs. preterm labor and delivery without these placental lesions (median 8.79 ng/mL; IQR, 4.98-14.7; P=0.028)]; (2) patients with preterm labor and chronic chorioamnionitis had higher AF concentrations of CXCL9 and CXCL10, but not CXCR3, than those without this lesion [CXCR3: preterm labor with chronic chorioamnionitis (median, 17.02 ng/mL; IQR, 5.57-26.68) vs. preterm labor without chronic chorioamnionitis (median, 10.37 ng/mL; IQR 5.01-17.81; P=0.283)]; (3) patients with preterm labor had a significantly higher AF concentration of CXCR3 than those in labor at term regardless of the presence or absence of placental lesions. Conclusion: Our findings support a role for maternal anti-fetal rejection in a subset of patients with preterm labor.
KW - Chronic chorioamnionitis
KW - CXCL10
KW - CXCL9
KW - maternal anti-fetal rejection
KW - preterm labor
KW - T cell
UR - http://www.scopus.com/inward/record.url?scp=85031030771&partnerID=8YFLogxK
U2 - 10.1515/jpm-2017-0042
DO - 10.1515/jpm-2017-0042
M3 - Article
C2 - 28829757
AN - SCOPUS:85031030771
SN - 0300-5577
VL - 46
SP - 123
EP - 137
JO - Journal of Perinatal Medicine
JF - Journal of Perinatal Medicine
IS - 2
ER -