CHRONIC HUMAN NERVE COMPRESSION – A HISTOLOGICAL ASSESSMENT

S. E. MACKINNON, A. L. DELLON, A. R. HUDSON, D. A. HUNTER

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

While compression neuropathy is a common clinical problem, the opportunity to study human nerve material is rare. A histological assessment of the superficial radial nerve of four human cases with entrapment syndrome is reported. Changes in the perineurium and the endoneurial microvessels as well as the presence of Renaut bodies were the earliest histological abnormalities noted. Connective tissue changes included epineurial and perineurial fibrosis. Nerve fibre pathology varied from fascicle to fascicle. The myelinated and unmyelinated fibre populations responded differently to this compression. In the myelinated fibre population, marked thinning of the myelin was noted. In the unmyelinated fibre population, a shift in the fibre histogram due to a new population of very small fibres was observed suggesting degeneration with subsequent regeneration of this fibre population.

Original languageEnglish
Pages (from-to)547-565
Number of pages19
JournalNeuropathology and Applied Neurobiology
Volume12
Issue number6
DOIs
StatePublished - Nov 1986
Externally publishedYes

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