Chronic granulomatous disease presenting in a 69-year-old man

Brian L. Schapiro, Mark S. Klempner, Peter E. Newburger, Mary C. Dinauer

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


CHRONIC granulomatous disease is a rare inherited disease characterized by severe recurrent bacterial and fungal infections beginning in childhood.1 Phagocytes from patients with chronic granulomatous disease exhibit defective killing of ingested microorganisms because of deficient production of Superoxide and related microbial oxidants by the NADPH oxidase of the phagocyte. The active oxidase complex is composed of both membrane and cytosolic proteins that catalyze the one-electron transfer from NADPH to oxygen, thus forming Superoxide.2 It is now recognized that chronic granulomatous disease can result from genetic defects in at least four different oxidase polypeptides. The most common form of chronic granulomatous.

Original languageEnglish
Pages (from-to)1786-1790
Number of pages5
JournalNew England Journal of Medicine
Issue number25
StatePublished - Dec 19 1991


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