TY - JOUR
T1 - Chromosomal mapping of five mouse g protein γ subunits
AU - Downes, Gerald B.
AU - Gilbert, Debra J.
AU - Copeland, Neal G.
AU - Gautam, N.
AU - Jenkins, Nancy A.
N1 - Funding Information:
This work was supported by National Institutes of Health Grant GM 46963 and the National Cancer Institute, DHHS, under contract with ABL. G.B.D. was supported by NIGMS predoctoral fellowship GM 17289-04. N.G. was supported by the American Heart Association. We thank Dr. Paul Goodfellow for critical discussions and valuable advice and Deborah B. Householder and Andreé Reuss for excellent technical assistance.
PY - 1999/4/1
Y1 - 1999/4/1
N2 - Heterotrimeric G proteins, composed of α,β, and γ subunits, transduce signals from transmembrane receptors to a wide range of intracellular effectors. The G protein γ subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Using an interspecific backcross panel, we have determined the mouse chromosomal locations of five γ subunit genes: γ2, γ8, γ10, γ12, and γCone. Combined with previous mapping studies, these data indicate that, with the possible exception of γ1 and γ11, the G protein γ subunit genes are well dispersed within the mouse and human genomes.
AB - Heterotrimeric G proteins, composed of α,β, and γ subunits, transduce signals from transmembrane receptors to a wide range of intracellular effectors. The G protein γ subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Using an interspecific backcross panel, we have determined the mouse chromosomal locations of five γ subunit genes: γ2, γ8, γ10, γ12, and γCone. Combined with previous mapping studies, these data indicate that, with the possible exception of γ1 and γ11, the G protein γ subunit genes are well dispersed within the mouse and human genomes.
UR - https://www.scopus.com/pages/publications/0344096618
U2 - 10.1006/geno.1999.5763
DO - 10.1006/geno.1999.5763
M3 - Article
C2 - 10191100
AN - SCOPUS:0344096618
SN - 0888-7543
VL - 57
SP - 173
EP - 176
JO - Genomics
JF - Genomics
IS - 1
ER -