Chromosomal mapping of five mouse g protein γ subunits

Gerald B. Downes, Debra J. Gilbert, Neal G. Copeland, N. Gautam, Nancy A. Jenkins

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Heterotrimeric G proteins, composed of α,β, and γ subunits, transduce signals from transmembrane receptors to a wide range of intracellular effectors. The G protein γ subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Using an interspecific backcross panel, we have determined the mouse chromosomal locations of five γ subunit genes: γ2, γ8, γ10, γ12, and γCone. Combined with previous mapping studies, these data indicate that, with the possible exception of γ1 and γ11, the G protein γ subunit genes are well dispersed within the mouse and human genomes.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalGenomics
Volume57
Issue number1
DOIs
StatePublished - Apr 1 1999

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    Downes, G. B., Gilbert, D. J., Copeland, N. G., Gautam, N., & Jenkins, N. A. (1999). Chromosomal mapping of five mouse g protein γ subunits. Genomics, 57(1), 173-176. https://doi.org/10.1006/geno.1999.5763