Chrome congestive heart failure: Study of low dosage prostaglandin-usages and complications

G. K. Singh, L. V. Fong, A. P. Salmon, B. R. Keeton

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Low dosage intravenous (<0·01 μg. kg-1. min-1) and oral prostaglandin E have been reported to produce fewer complications than higher intravenous doses in the ductal manipulation of congenital heart disease. Over a 3-year period 34 patients were treated with low dosage intravenous or oral prosraglandin. Eighteen (53%) had complications associated with this treatment with 14 having more than one complication. Major complications occurred in nine neonates: necrotising enterocolitis (7), apnoealbradycardia (5), convulsions (1), haemorrhage (1), and resulted in a change of management. This study therefore concludes that the high incidence of complications is similar with both low and high dosages of intravenous and oral prostaglandmn. The use of prostaglandin in any form deserves caution.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalEuropean heart journal
Volume15
Issue number3
DOIs
StatePublished - Mar 1994
Externally publishedYes

Keywords

  • Complication
  • Congenital heart disease
  • Low dosage prostaglandin E

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