TY - JOUR
T1 - Chromatin and epigenetics in aging biology
AU - Greer, Eric Lieberman
AU - Lee, Siu Sylvia
AU - Prahlad, Veena
N1 - Publisher Copyright:
© 2025 The Author(s). Published by Oxford University Press on behalf of The Genetics Society of America. All rights reserved.
PY - 2025/5/1
Y1 - 2025/5/1
N2 - This book chapter will focus on modifications to chromatin itself, how chromatin modifications are regulated, and how these modifications are deciphered by the cell to impact aging. In this chapter, we will review how chromatin modifications change with age, examine how chromatin-modifying enzymes have been shown to regulate aging and healthspan, discuss how some of these epigenetic changes are triggered and how they can regulate the lifespan of the individual and its naïve descendants, and speculate on future directions for the field.
AB - This book chapter will focus on modifications to chromatin itself, how chromatin modifications are regulated, and how these modifications are deciphered by the cell to impact aging. In this chapter, we will review how chromatin modifications change with age, examine how chromatin-modifying enzymes have been shown to regulate aging and healthspan, discuss how some of these epigenetic changes are triggered and how they can regulate the lifespan of the individual and its naïve descendants, and speculate on future directions for the field.
KW - aging
KW - chromatin
KW - epigenetics
KW - histone modifications
KW - WormBook
UR - https://www.scopus.com/pages/publications/105004738644
U2 - 10.1093/genetics/iyaf055
DO - 10.1093/genetics/iyaf055
M3 - Review article
C2 - 40202900
AN - SCOPUS:105004738644
SN - 0016-6731
VL - 230
JO - Genetics
JF - Genetics
IS - 1
M1 - iyaf055
ER -