TY - JOUR
T1 - Chromatin accessibility in neuropsychiatric disorders
AU - Egervari, Gabor
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/5
Y1 - 2021/5
N2 - Epigenetic mechanisms have recently emerged as critical regulators of brain function in health and disease. By controlling the accessibility and the expression of specific genes, these pathways can mediate transient and long-lasting changes in neuronal function in both physiological and pathological contexts. Due to the extreme complexity of the epigenetic regulatory landscape, emerging methods that directly assay chromatin accessibility are of particular interest. Here, I review recent insights gained on open and closed chromatin states in the brain, with emphasis on neuropsychiatric disorders. These advances generated an invaluable wealth of information that can help us better understand gene regulation in the brain and its impairments that contribute to the development of disease.
AB - Epigenetic mechanisms have recently emerged as critical regulators of brain function in health and disease. By controlling the accessibility and the expression of specific genes, these pathways can mediate transient and long-lasting changes in neuronal function in both physiological and pathological contexts. Due to the extreme complexity of the epigenetic regulatory landscape, emerging methods that directly assay chromatin accessibility are of particular interest. Here, I review recent insights gained on open and closed chromatin states in the brain, with emphasis on neuropsychiatric disorders. These advances generated an invaluable wealth of information that can help us better understand gene regulation in the brain and its impairments that contribute to the development of disease.
KW - Brain
KW - Chromatin accessibility
KW - Neuropsychiatric disease
UR - http://www.scopus.com/inward/record.url?scp=85104286075&partnerID=8YFLogxK
U2 - 10.1016/j.nlm.2021.107438
DO - 10.1016/j.nlm.2021.107438
M3 - Review article
C2 - 33845131
AN - SCOPUS:85104286075
SN - 1074-7427
VL - 181
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
M1 - 107438
ER -