Choosing the correct functional assay: A comprehensive assessment of functional tests in the rat

Chris M. Nichols, Terence M. Myckatyn, Susan R. Rickman, Ida K. Fox, Tessa Hadlock, Susan E. Mackinnon

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

While there are several ways to quantify peripheral nerve regeneration; the true measure of successful outcome is functional recovery. Functional tests are relatively easily conducted in human subjects; however it is more difficult in a laboratory animal. The laboratory rat is an excellent animal model of peripheral nerve injury and has been used extensively in the field of peripheral nerve research. Due to the intense interest in the rat as an experimental model, functional assays have been reported. In an effort to provide a resource to which investigators can refer when considering the most appropriate functional assay for a given experiment, the authors have compiled and tabulated the available functional tests applicable to various models of rat nerve injury.

Original languageEnglish
Pages (from-to)143-158
Number of pages16
JournalBehavioural Brain Research
Volume163
Issue number2
DOIs
StatePublished - Sep 8 2005

Keywords

  • Forelimb
  • Functional test
  • Hind limb
  • Motor
  • Nerve
  • Rat
  • Sensory
  • Vibrissae

Fingerprint Dive into the research topics of 'Choosing the correct functional assay: A comprehensive assessment of functional tests in the rat'. Together they form a unique fingerprint.

  • Cite this