Choosing the correct functional assay: A comprehensive assessment of functional tests in the rat

Chris M. Nichols; Terence M. Myckatyn; Susan R. Rickman; Ida K. Fox; Tessa Hadlock; Susan E. Mackinnon

doi:10.1016/j.bbr.2005.05.003

Choosing the correct functional assay: A comprehensive assessment of functional tests in the rat

Chris M. Nichols, Terence M. Myckatyn, Susan R. Rickman, Ida K. Fox, Tessa Hadlock, Susan E. Mackinnon

Research output: Contribution to journal › Review article › peer-review

97 Scopus citations

Abstract

While there are several ways to quantify peripheral nerve regeneration; the true measure of successful outcome is functional recovery. Functional tests are relatively easily conducted in human subjects; however it is more difficult in a laboratory animal. The laboratory rat is an excellent animal model of peripheral nerve injury and has been used extensively in the field of peripheral nerve research. Due to the intense interest in the rat as an experimental model, functional assays have been reported. In an effort to provide a resource to which investigators can refer when considering the most appropriate functional assay for a given experiment, the authors have compiled and tabulated the available functional tests applicable to various models of rat nerve injury.

Original language	English
Pages (from-to)	143-158
Number of pages	16
Journal	Behavioural Brain Research
Volume	163
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2005.05.003
State	Published - Sep 8 2005

Keywords

Forelimb
Functional test
Hind limb
Motor
Nerve
Rat
Sensory
Vibrissae

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10.1016/j.bbr.2005.05.003

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abstract = "While there are several ways to quantify peripheral nerve regeneration; the true measure of successful outcome is functional recovery. Functional tests are relatively easily conducted in human subjects; however it is more difficult in a laboratory animal. The laboratory rat is an excellent animal model of peripheral nerve injury and has been used extensively in the field of peripheral nerve research. Due to the intense interest in the rat as an experimental model, functional assays have been reported. In an effort to provide a resource to which investigators can refer when considering the most appropriate functional assay for a given experiment, the authors have compiled and tabulated the available functional tests applicable to various models of rat nerve injury.",

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AU - Hadlock, Tessa

AU - Mackinnon, Susan E.

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AB - While there are several ways to quantify peripheral nerve regeneration; the true measure of successful outcome is functional recovery. Functional tests are relatively easily conducted in human subjects; however it is more difficult in a laboratory animal. The laboratory rat is an excellent animal model of peripheral nerve injury and has been used extensively in the field of peripheral nerve research. Due to the intense interest in the rat as an experimental model, functional assays have been reported. In an effort to provide a resource to which investigators can refer when considering the most appropriate functional assay for a given experiment, the authors have compiled and tabulated the available functional tests applicable to various models of rat nerve injury.

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Choosing the correct functional assay: A comprehensive assessment of functional tests in the rat

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