Chondro-osseous respiratory epithelial adenomatoid hamartoma of the nasal cavity

Faysal Fedda, Fouad Boulos, Alain Sabri

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9 Scopus citations


Introduction: Chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH) is a benign lesion of the nose and sinuses that is extremely rare, with only 2 cases reported in the literature to date. Case report: We present herein the third reported case of COREAH, in a 38-year-old woman who presented with left nasal obstruction and a mass in her left nasal cavity. The mass was completely resected endoscopically. Microscopic examination showed hamartomatous proliferation of respiratory-type glands with mucinous metaplasia admixed with numerous spicules of mature bone, characteristic of COREAH. Conclusion: COREAH is a benign hamartomatous proliferation of respiratory epithelium, submucosal glands, and chondroosseous mesenchyme. The clinical differential diagnoses for such lesions include glandular hamartoma, inflammatory polyp, inverted papilloma, and low-grade sinonasal adenocarcinoma. Recognition of this lesion as benign despite its potentially worrisome radiographic appearance is important to avoid an unnecessarily radical surgical procedure.

Original languageEnglish
Pages (from-to)218-221
Number of pages4
JournalInternational Archives of Otorhinolaryngology
Issue number2
StatePublished - Apr 2013


  • Hamartoma
  • Nasal cavity
  • Nasal polyps


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