Cholinergic imbalance in lumbar spinal cord of a rat model of multiple sclerosis

Chunling Liu, Hui Liu, Hongjun Jin, Xuyi Yue, Zonghua Luo, Zhude Tu

Research output: Contribution to journalArticlepeer-review


Cholinergic dysfunction in the central nervous system is an important characteristic of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). By using a rat EAE model, upregulation of vesicular acetylcholine transporter (VAChT) level in the EAE rat lumbar spinal cord was detected by western blot and immunostaining, and was associated with lymphocyte filtration and glial activation. Ex vivo and in vitro autoradiography studies with [18F]VAT, a VAChT-specific radioligand, also revealed increased tracer uptake in EAE rat lumbar spinal cord compared with shams. These studies on VAChT expression suggest central cholinergic imbalance during EAE progression.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalJournal of Neuroimmunology
StatePublished - May 15 2018


  • Experimental autoimmune encephalomyelitis
  • Neuroinflammation
  • Vesicular acetylcholine transporter


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