Cholestyramine‐Induced Hyperchloremic Metabolic Acidosis

Paul J. Scheel; Andrew Whelton; Kevin Rossiter; Alan Watson

doi:10.1177/009127009203200608

Cholestyramine‐Induced Hyperchloremic Metabolic Acidosis

Paul J. Scheel, Andrew Whelton, Kevin Rossiter, Alan Watson

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Abstract

Cholestyramine is a nonabsorbable anion exchange resin that is used predominantly for the treatment of hypercholesterolemia in adults and the management of acute diarrhea in children. The authors report two cases of severe hyperchloremic nonanion gap metabolic acidosis associated with the use of cholestyramine therapy. The authors recommend that patients taking cholestyramine who have concomitant renal insufficiency or who are volume depleted or who are taking spironolactone be monitored carefully for the emergence of a hyperchloremic metabolic acidosis. 1992 American College of Clinical Pharmacology

Original language	English
Pages (from-to)	536-538
Number of pages	3
Journal	The Journal of Clinical Pharmacology
Volume	32
Issue number	6
DOIs	https://doi.org/10.1177/009127009203200608
State	Published - Jun 1992

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title = "Cholestyramine‐Induced Hyperchloremic Metabolic Acidosis",

abstract = "Cholestyramine is a nonabsorbable anion exchange resin that is used predominantly for the treatment of hypercholesterolemia in adults and the management of acute diarrhea in children. The authors report two cases of severe hyperchloremic nonanion gap metabolic acidosis associated with the use of cholestyramine therapy. The authors recommend that patients taking cholestyramine who have concomitant renal insufficiency or who are volume depleted or who are taking spironolactone be monitored carefully for the emergence of a hyperchloremic metabolic acidosis. 1992 American College of Clinical Pharmacology",

author = "Scheel, {Paul J.} and Andrew Whelton and Kevin Rossiter and Alan Watson",

year = "1992",

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AU - Scheel, Paul J.

AU - Whelton, Andrew

AU - Rossiter, Kevin

AU - Watson, Alan

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AB - Cholestyramine is a nonabsorbable anion exchange resin that is used predominantly for the treatment of hypercholesterolemia in adults and the management of acute diarrhea in children. The authors report two cases of severe hyperchloremic nonanion gap metabolic acidosis associated with the use of cholestyramine therapy. The authors recommend that patients taking cholestyramine who have concomitant renal insufficiency or who are volume depleted or who are taking spironolactone be monitored carefully for the emergence of a hyperchloremic metabolic acidosis. 1992 American College of Clinical Pharmacology

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JO - The Journal of Clinical Pharmacology

JF - The Journal of Clinical Pharmacology

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ER -

Cholestyramine‐Induced Hyperchloremic Metabolic Acidosis

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