Cholecystokinin reduces exploratory behavior in mice

Jacqueline N. Crawley, Sally E. Hays, Steven M. Paul, Frederick K. Goodwin

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


The role of cholecystokinin (CCK) in mediating spontaneous behaviors in mice was analyzed, using a video-tracking, computer-assisted animal behavior monitoring system. Intraperitoneal administration of cholecystokinin octapeptide decreased investigation of environmental objects and interactions with a female mouse, while increasing the amount of time spent in the corners of the test arena and the duration of non-exploratory pauses. Dose-dependent effects were seen in the range of 0.12-50 μg/kg. Other parameters of motor activity were normal, indicating that the reduction in exploratory tendencies is not a function of sedation or loss of motor coordination. Neither gastrin nor unsulfated cholecystokinin8 changed any of the measured parameters, indicating pharmacological specificity for the observed reduction in exploration.

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalPhysiology and Behavior
Issue number3
StatePublished - Sep 1981


  • Cholecystokinin
  • Exploratory behavior
  • Mouse behavior
  • Neuropeptides


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