Cholecystokinin receptors are decreased in basal ganglia and cerebral cortex of Huntington's disease

Sally E. Hays, Frederick K. Goodwin, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Cholecystokinin (CCK) receptors were found to be significantly reduced in basal ganglia and cerebral cortex of post-mortem brains from Huntington's patients as compared with matched controls. The magnitude of the reduction in CCK binding (69% in basal ganglia, 43% in cerebral cortex) is consistent with the degree of neuronal degeneration in basal ganglia, but suggests a possibly selective loss of CCK receptor-containing neurons in cerebral cortex of Huntington's patients.

Original languageEnglish
Pages (from-to)452-456
Number of pages5
JournalBrain Research
Volume225
Issue number2
DOIs
StatePublished - Nov 30 1981

Keywords

  • Huntington's disease
  • basal ganglia
  • cerebral cortex
  • cholecystokinin receptors

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