Cholecystokinin receptors are decreased in basal ganglia and cerebral cortex of Huntington's disease

Sally E. Hays; Frederick K. Goodwin; Steven M. Paul

doi:10.1016/0006-8993(81)90853-2

Cholecystokinin receptors are decreased in basal ganglia and cerebral cortex of Huntington's disease

Sally E. Hays, Frederick K. Goodwin, Steven M. Paul

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Cholecystokinin (CCK) receptors were found to be significantly reduced in basal ganglia and cerebral cortex of post-mortem brains from Huntington's patients as compared with matched controls. The magnitude of the reduction in CCK binding (69% in basal ganglia, 43% in cerebral cortex) is consistent with the degree of neuronal degeneration in basal ganglia, but suggests a possibly selective loss of CCK receptor-containing neurons in cerebral cortex of Huntington's patients.

Original language	English
Pages (from-to)	452-456
Number of pages	5
Journal	Brain Research
Volume	225
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(81)90853-2
State	Published - Nov 30 1981

Keywords

Huntington's disease
basal ganglia
cerebral cortex
cholecystokinin receptors

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10.1016/0006-8993(81)90853-2

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abstract = "Cholecystokinin (CCK) receptors were found to be significantly reduced in basal ganglia and cerebral cortex of post-mortem brains from Huntington's patients as compared with matched controls. The magnitude of the reduction in CCK binding (69% in basal ganglia, 43% in cerebral cortex) is consistent with the degree of neuronal degeneration in basal ganglia, but suggests a possibly selective loss of CCK receptor-containing neurons in cerebral cortex of Huntington's patients.",

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AU - Goodwin, Frederick K.

AU - Paul, Steven M.

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Y1 - 1981/11/30

N2 - Cholecystokinin (CCK) receptors were found to be significantly reduced in basal ganglia and cerebral cortex of post-mortem brains from Huntington's patients as compared with matched controls. The magnitude of the reduction in CCK binding (69% in basal ganglia, 43% in cerebral cortex) is consistent with the degree of neuronal degeneration in basal ganglia, but suggests a possibly selective loss of CCK receptor-containing neurons in cerebral cortex of Huntington's patients.

AB - Cholecystokinin (CCK) receptors were found to be significantly reduced in basal ganglia and cerebral cortex of post-mortem brains from Huntington's patients as compared with matched controls. The magnitude of the reduction in CCK binding (69% in basal ganglia, 43% in cerebral cortex) is consistent with the degree of neuronal degeneration in basal ganglia, but suggests a possibly selective loss of CCK receptor-containing neurons in cerebral cortex of Huntington's patients.

KW - Huntington's disease

KW - basal ganglia

KW - cerebral cortex

KW - cholecystokinin receptors

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ER -

Cholecystokinin receptors are decreased in basal ganglia and cerebral cortex of Huntington's disease

Abstract

Keywords

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