Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

Wei Fan; Kate L.J. Ellacott; Ilia G. Halatchev; Kanji Takahashi; Pinxuan Yu; Roger D. Cone

doi:10.1038/nn1214

Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

Wei Fan, Kate L.J. Ellacott, Ilia G. Halatchev, Kanji Takahashi, Pinxuan Yu, Roger D. Cone

Research output: Contribution to journal › Article › peer-review

270 Scopus citations

Abstract

Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.

Original language	English
Pages (from-to)	335-336
Number of pages	2
Journal	Nature neuroscience
Volume	7
Issue number	4
DOIs	https://doi.org/10.1038/nn1214
State	Published - Apr 2004

Access to Document

10.1038/nn1214

Cite this

@article{59050ae28ed241ec9bd779bc3f97d2cb,

title = "Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system",

abstract = "Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.",

author = "Wei Fan and Ellacott, {Kate L.J.} and Halatchev, {Ilia G.} and Kanji Takahashi and Pinxuan Yu and Cone, {Roger D.}",

note = "Funding Information: Supported by US National Institutes of Health grants DK55819 (R.D.C.) and DK62179 (W.F.), and a grant from the Wellcome Trust (K.L.J.E.). POMC-EGFP mice were a kind gift of M. Low (Oregon Health and Science University).",

year = "2004",

month = apr,

doi = "10.1038/nn1214",

language = "English",

volume = "7",

pages = "335--336",

journal = "Nature neuroscience",

issn = "1097-6256",

number = "4",

}

TY - JOUR

T1 - Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

AU - Fan, Wei

AU - Ellacott, Kate L.J.

AU - Halatchev, Ilia G.

AU - Takahashi, Kanji

AU - Yu, Pinxuan

AU - Cone, Roger D.

N1 - Funding Information: Supported by US National Institutes of Health grants DK55819 (R.D.C.) and DK62179 (W.F.), and a grant from the Wellcome Trust (K.L.J.E.). POMC-EGFP mice were a kind gift of M. Low (Oregon Health and Science University).

PY - 2004/4

Y1 - 2004/4

N2 - Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.

AB - Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.

UR - http://www.scopus.com/inward/record.url?scp=1842560331&partnerID=8YFLogxK

U2 - 10.1038/nn1214

DO - 10.1038/nn1214

M3 - Article

C2 - 15034587

AN - SCOPUS:1842560331

SN - 1097-6256

VL - 7

SP - 335

EP - 336

JO - Nature neuroscience

JF - Nature neuroscience

IS - 4

ER -

Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

Abstract

Access to Document

Other files and links

Fingerprint

Cite this