Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

Wei Fan, Kate L.J. Ellacott, Ilia G. Halatchev, Kanji Takahashi, Pinxuan Yu, Roger D. Cone

Research output: Contribution to journalArticle

223 Scopus citations

Abstract

Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.

Original languageEnglish
Pages (from-to)335-336
Number of pages2
JournalNature neuroscience
Volume7
Issue number4
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

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