Chitins and chitinase activity in airway diseases

Steven J. Van Dyken, Richard M. Locksley

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Chitin, one of the most abundant biopolymers on Earth, is bound and degraded by chitinases, specialized enzymes that are similarly widespread in nature. Chitin catabolism affects global carbon and nitrogen cycles through a host of diverse biological processes, but recent work has focused attention on systems of chitin recognition and degradation conserved in mammals, connecting an ancient pathway of polysaccharide processing to human diseases influenced by persistent immune triggering. Here we review current advances in our understanding of how chitin-chitinase interactions affect mucosal immune feedback mechanisms essential to maintaining homeostasis and organ health.

Original languageEnglish
Pages (from-to)364-369
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Volume142
Issue number2
DOIs
StatePublished - Aug 2018

Keywords

  • Acidic mammalian chitinase
  • age-related disease
  • chitin
  • chitinase
  • chitotriosidase
  • epithelium
  • fibrosis
  • innate lymphoid cell
  • interleukins
  • interstitial lung disease
  • polysaccharide
  • pulmonary fibrosis

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