TY - JOUR
T1 - Chitins and chitinase activity in airway diseases
AU - Van Dyken, Steven J.
AU - Locksley, Richard M.
N1 - Publisher Copyright:
© 2018 American Academy of Allergy, Asthma & Immunology
PY - 2018/8
Y1 - 2018/8
N2 - Chitin, one of the most abundant biopolymers on Earth, is bound and degraded by chitinases, specialized enzymes that are similarly widespread in nature. Chitin catabolism affects global carbon and nitrogen cycles through a host of diverse biological processes, but recent work has focused attention on systems of chitin recognition and degradation conserved in mammals, connecting an ancient pathway of polysaccharide processing to human diseases influenced by persistent immune triggering. Here we review current advances in our understanding of how chitin-chitinase interactions affect mucosal immune feedback mechanisms essential to maintaining homeostasis and organ health.
AB - Chitin, one of the most abundant biopolymers on Earth, is bound and degraded by chitinases, specialized enzymes that are similarly widespread in nature. Chitin catabolism affects global carbon and nitrogen cycles through a host of diverse biological processes, but recent work has focused attention on systems of chitin recognition and degradation conserved in mammals, connecting an ancient pathway of polysaccharide processing to human diseases influenced by persistent immune triggering. Here we review current advances in our understanding of how chitin-chitinase interactions affect mucosal immune feedback mechanisms essential to maintaining homeostasis and organ health.
KW - Acidic mammalian chitinase
KW - age-related disease
KW - chitin
KW - chitinase
KW - chitotriosidase
KW - epithelium
KW - fibrosis
KW - innate lymphoid cell
KW - interleukins
KW - interstitial lung disease
KW - polysaccharide
KW - pulmonary fibrosis
UR - http://www.scopus.com/inward/record.url?scp=85050544863&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2018.06.017
DO - 10.1016/j.jaci.2018.06.017
M3 - Article
C2 - 29959948
AN - SCOPUS:85050544863
SN - 0091-6749
VL - 142
SP - 364
EP - 369
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 2
ER -