Children's Oncology Group's 2013 blueprint for research: Renal tumors

Jeffrey S. Dome; Conrad V. Fernandez; Elizabeth A. Mullen; John A. Kalapurakal; James I. Geller; Vicki Huff; Eric J. Gratias; David B. Dix; Peter F. Ehrlich; Geetika Khanna; Marcio H. Malogolowkin; James R. Anderson; Arlene Naranjo; Elizabeth J. Perlman

doi:10.1002/pbc.24419

Children's Oncology Group's 2013 blueprint for research: Renal tumors

Jeffrey S. Dome, Conrad V. Fernandez, Elizabeth A. Mullen, John A. Kalapurakal, James I. Geller, Vicki Huff, Eric J. Gratias, David B. Dix, Peter F. Ehrlich, Geetika Khanna, Marcio H. Malogolowkin, James R. Anderson, Arlene Naranjo, Elizabeth J. Perlman

Department of Radiology

Research output: Contribution to journal › Review article › peer-review

126 Scopus citations

Abstract

Renal malignancies are among the most prevalent pediatric cancers. The most common is favorable histology Wilms tumor (FHWT), which has 5-year overall survival exceeding 90%. Other pediatric renal malignancies, including anaplastic Wilms tumor, clear cell sarcoma, malignant rhabdoid tumor, and renal cell carcinoma, have less favorable outcomes. Recent clinical trials have identified gain of chromosome 1q as a prognostic marker for FHWT. Upcoming studies will evaluate therapy adjustments based on this and other novel biomarkers. For high-risk renal tumors, new treatment regimens will incorporate biological therapies. A research blueprint, viewed from the perspective of the Children's Oncology Group, is presented.

Original language	English
Pages (from-to)	994-1000
Number of pages	7
Journal	Pediatric Blood and Cancer
Volume	60
Issue number	6
DOIs	https://doi.org/10.1002/pbc.24419
State	Published - Jun 2013

Keywords

Clear cell sarcoma
Malignant rhabdoid tumor
Renal cell carcinoma
Wilms tumor

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10.1002/pbc.24419

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Dome, J. S., Fernandez, C. V., Mullen, E. A., Kalapurakal, J. A., Geller, J. I., Huff, V., Gratias, E. J., Dix, D. B., Ehrlich, P. F., Khanna, G., Malogolowkin, M. H., Anderson, J. R., Naranjo, A., & Perlman, E. J. (2013). Children's Oncology Group's 2013 blueprint for research: Renal tumors. Pediatric Blood and Cancer, 60(6), 994-1000. https://doi.org/10.1002/pbc.24419

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title = "Children's Oncology Group's 2013 blueprint for research: Renal tumors",

abstract = "Renal malignancies are among the most prevalent pediatric cancers. The most common is favorable histology Wilms tumor (FHWT), which has 5-year overall survival exceeding 90%. Other pediatric renal malignancies, including anaplastic Wilms tumor, clear cell sarcoma, malignant rhabdoid tumor, and renal cell carcinoma, have less favorable outcomes. Recent clinical trials have identified gain of chromosome 1q as a prognostic marker for FHWT. Upcoming studies will evaluate therapy adjustments based on this and other novel biomarkers. For high-risk renal tumors, new treatment regimens will incorporate biological therapies. A research blueprint, viewed from the perspective of the Children's Oncology Group, is presented.",

keywords = "Clear cell sarcoma, Malignant rhabdoid tumor, Renal cell carcinoma, Wilms tumor",

author = "Dome, {Jeffrey S.} and Fernandez, {Conrad V.} and Mullen, {Elizabeth A.} and Kalapurakal, {John A.} and Geller, {James I.} and Vicki Huff and Gratias, {Eric J.} and Dix, {David B.} and Ehrlich, {Peter F.} and Geetika Khanna and Malogolowkin, {Marcio H.} and Anderson, {James R.} and Arlene Naranjo and Perlman, {Elizabeth J.}",

year = "2013",

month = jun,

doi = "10.1002/pbc.24419",

language = "English",

volume = "60",

pages = "994--1000",

journal = "Pediatric Blood and Cancer",

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T2 - Renal tumors

AU - Dome, Jeffrey S.

AU - Fernandez, Conrad V.

AU - Mullen, Elizabeth A.

AU - Kalapurakal, John A.

AU - Geller, James I.

AU - Huff, Vicki

AU - Gratias, Eric J.

AU - Dix, David B.

AU - Ehrlich, Peter F.

AU - Khanna, Geetika

AU - Malogolowkin, Marcio H.

AU - Anderson, James R.

AU - Naranjo, Arlene

AU - Perlman, Elizabeth J.

PY - 2013/6

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N2 - Renal malignancies are among the most prevalent pediatric cancers. The most common is favorable histology Wilms tumor (FHWT), which has 5-year overall survival exceeding 90%. Other pediatric renal malignancies, including anaplastic Wilms tumor, clear cell sarcoma, malignant rhabdoid tumor, and renal cell carcinoma, have less favorable outcomes. Recent clinical trials have identified gain of chromosome 1q as a prognostic marker for FHWT. Upcoming studies will evaluate therapy adjustments based on this and other novel biomarkers. For high-risk renal tumors, new treatment regimens will incorporate biological therapies. A research blueprint, viewed from the perspective of the Children's Oncology Group, is presented.

AB - Renal malignancies are among the most prevalent pediatric cancers. The most common is favorable histology Wilms tumor (FHWT), which has 5-year overall survival exceeding 90%. Other pediatric renal malignancies, including anaplastic Wilms tumor, clear cell sarcoma, malignant rhabdoid tumor, and renal cell carcinoma, have less favorable outcomes. Recent clinical trials have identified gain of chromosome 1q as a prognostic marker for FHWT. Upcoming studies will evaluate therapy adjustments based on this and other novel biomarkers. For high-risk renal tumors, new treatment regimens will incorporate biological therapies. A research blueprint, viewed from the perspective of the Children's Oncology Group, is presented.

KW - Clear cell sarcoma

KW - Malignant rhabdoid tumor

KW - Renal cell carcinoma

KW - Wilms tumor

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DO - 10.1002/pbc.24419

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SN - 1545-5009

VL - 60

SP - 994

EP - 1000

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 6

ER -

Children's Oncology Group's 2013 blueprint for research: Renal tumors

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