Childhood B-acute lymphoblastic leukemia: A genetic update

Jennifer S. Woo, Michael O. Alberti, Carlos A. Tirado

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations

Abstract

In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood hematological malignancy, as well as the leading cause of childhood cancer-related mortality. Advances in cytogenetics utilizing array-based technologies and next-generation sequencing (NGS) techniques have revealed exciting insights into the genetic basis of this disease, with the hopes of developing individualized treatment plans for affected children. In this comprehensive review, we discuss our current understanding of childhood (pediatric) B-ALL and highlight the most recent genetic advances and their therapeutic implications.

Original languageEnglish
Article number16
JournalExperimental Hematology and Oncology
Volume3
Issue number1
DOIs
StatePublished - Jun 13 2014

Keywords

  • B-cell
  • B-precursor
  • Cytogenetics
  • Genetics
  • Pediatric B-ALL

Fingerprint

Dive into the research topics of 'Childhood B-acute lymphoblastic leukemia: A genetic update'. Together they form a unique fingerprint.

Cite this