TY - JOUR
T1 - Chikungunya infection in pregnancy – reassuring maternal and perinatal outcomes
T2 - a retrospective observational study
AU - Foeller, M. E.
AU - Nosrat, C.
AU - Krystosik, A.
AU - Noel, T.
AU - Gérardin, P.
AU - Cudjoe, N.
AU - Mapp-Alexander, V.
AU - Mitchell, G.
AU - Macpherson, C.
AU - Waechter, R.
AU - LaBeaud, A. D.
N1 - Funding Information:
This study was funded by NIH Fogarty International Center, grant #1R21TW010536‐01 (PIs Waechter and LaBeaud, with the help of Patrick Gérardin).
Funding Information:
MEF is a consultant for the World Health Organization and ADL received grant funding from the NIH for a R21 during the study period. No other authors have any disclosures. The authors report no conflicts of interest. Completed disclosure of interest forms are available to view online as supporting information.
Publisher Copyright:
© 2020 John Wiley & Sons Ltd.
PY - 2021/5
Y1 - 2021/5
N2 - Objective: To evaluate pregnancy and neonatal outcomes, disease severity, and mother-to-child transmission of pregnant women with Chikungunya infection (CHIKV). Design: Retrospective observational study. Setting: Grenada. Population: Women who gave birth during a Chikungunya outbreak between January 2014 and September 2015 were eligible. Methods: This descriptive study investigated 731 mother-infant pairs who gave birth during a CHIKV outbreak. Women and infants underwent serological testing for CHIKV by ELISA. Main outcome measures: Primary outcomes: composite pregnancy complication (abruption, vaginal bleeding, preterm labour/cervical incompetence, cesarean delivery for fetal distress/abruption/placental abnormality or delivery for fetal distress) and composite neonatal morbidity. Results: Of 416 mother-infant pairs, 150 (36%) had CHIKV during pregnancy, 135 (33%) had never had CHIKV, and 131 (31%) had CHIKV outside of pregnancy. Mean duration of joint pain was shorter among women infected during pregnancy (μ = 898 days, σ = 277 days) compared with infections outside of pregnancy (μ = 1064 days, σ = 244 days) (P < 0.0001). Rates of pregnancy complications (RR = 0.76, P = 0.599), intrapartum complications (RR = 1.50, P = 0.633), and neonatal outcomes were otherwise similar. Possible mother-to-child transmission occurred in two (1.3%) mother-infant pairs and two of eight intrapartum infections (25%). Conclusion: CHIKV infection during pregnancy may be protective against long-term joint pain sequelae that are often associated with acute CHIKV infection. Infection during pregnancy did not appear to pose a risk for pregnancy complications or neonatal health, but maternal infection just prior to delivery might have increased risk of mother-to-child transmission of CHIKV. Tweetable abstract: Chikungunya infection did not increase risk of pregnancy complications or adverse neonatal outcomes, unless infection was just prior to delivery.
AB - Objective: To evaluate pregnancy and neonatal outcomes, disease severity, and mother-to-child transmission of pregnant women with Chikungunya infection (CHIKV). Design: Retrospective observational study. Setting: Grenada. Population: Women who gave birth during a Chikungunya outbreak between January 2014 and September 2015 were eligible. Methods: This descriptive study investigated 731 mother-infant pairs who gave birth during a CHIKV outbreak. Women and infants underwent serological testing for CHIKV by ELISA. Main outcome measures: Primary outcomes: composite pregnancy complication (abruption, vaginal bleeding, preterm labour/cervical incompetence, cesarean delivery for fetal distress/abruption/placental abnormality or delivery for fetal distress) and composite neonatal morbidity. Results: Of 416 mother-infant pairs, 150 (36%) had CHIKV during pregnancy, 135 (33%) had never had CHIKV, and 131 (31%) had CHIKV outside of pregnancy. Mean duration of joint pain was shorter among women infected during pregnancy (μ = 898 days, σ = 277 days) compared with infections outside of pregnancy (μ = 1064 days, σ = 244 days) (P < 0.0001). Rates of pregnancy complications (RR = 0.76, P = 0.599), intrapartum complications (RR = 1.50, P = 0.633), and neonatal outcomes were otherwise similar. Possible mother-to-child transmission occurred in two (1.3%) mother-infant pairs and two of eight intrapartum infections (25%). Conclusion: CHIKV infection during pregnancy may be protective against long-term joint pain sequelae that are often associated with acute CHIKV infection. Infection during pregnancy did not appear to pose a risk for pregnancy complications or neonatal health, but maternal infection just prior to delivery might have increased risk of mother-to-child transmission of CHIKV. Tweetable abstract: Chikungunya infection did not increase risk of pregnancy complications or adverse neonatal outcomes, unless infection was just prior to delivery.
KW - Chikungunya
KW - mother-to-child-transmission
KW - neonatal outcomes
KW - pregnancy
KW - pregnancy outcomes
KW - vertical transmission
UR - http://www.scopus.com/inward/record.url?scp=85096725173&partnerID=8YFLogxK
U2 - 10.1111/1471-0528.16562
DO - 10.1111/1471-0528.16562
M3 - Article
C2 - 33040457
AN - SCOPUS:85096725173
SN - 1470-0328
VL - 128
SP - 1077
EP - 1086
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 6
ER -