Chikungunya infection in pregnancy – reassuring maternal and perinatal outcomes: a retrospective observational study

M. E. Foeller, C. Nosrat, A. Krystosik, T. Noel, P. Gérardin, N. Cudjoe, V. Mapp-Alexander, G. Mitchell, C. Macpherson, R. Waechter, A. D. LaBeaud

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate pregnancy and neonatal outcomes, disease severity, and mother-to-child transmission of pregnant women with Chikungunya infection (CHIKV). Design: Retrospective observational study. Setting: Grenada. Population: Women who gave birth during a Chikungunya outbreak between January 2014 and September 2015 were eligible. Methods: This descriptive study investigated 731 mother-infant pairs who gave birth during a CHIKV outbreak. Women and infants underwent serological testing for CHIKV by ELISA. Main outcome measures: Primary outcomes: composite pregnancy complication (abruption, vaginal bleeding, preterm labour/cervical incompetence, cesarean delivery for fetal distress/abruption/placental abnormality or delivery for fetal distress) and composite neonatal morbidity. Results: Of 416 mother-infant pairs, 150 (36%) had CHIKV during pregnancy, 135 (33%) had never had CHIKV, and 131 (31%) had CHIKV outside of pregnancy. Mean duration of joint pain was shorter among women infected during pregnancy (μ = 898 days, σ = 277 days) compared with infections outside of pregnancy (μ = 1064 days, σ = 244 days) (P < 0.0001). Rates of pregnancy complications (RR = 0.76, P = 0.599), intrapartum complications (RR = 1.50, P = 0.633), and neonatal outcomes were otherwise similar. Possible mother-to-child transmission occurred in two (1.3%) mother-infant pairs and two of eight intrapartum infections (25%). Conclusion: CHIKV infection during pregnancy may be protective against long-term joint pain sequelae that are often associated with acute CHIKV infection. Infection during pregnancy did not appear to pose a risk for pregnancy complications or neonatal health, but maternal infection just prior to delivery might have increased risk of mother-to-child transmission of CHIKV. Tweetable abstract: Chikungunya infection did not increase risk of pregnancy complications or adverse neonatal outcomes, unless infection was just prior to delivery.

Original languageEnglish
Pages (from-to)1077-1086
Number of pages10
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume128
Issue number6
DOIs
StatePublished - May 2021

Keywords

  • Chikungunya
  • mother-to-child-transmission
  • neonatal outcomes
  • pregnancy
  • pregnancy outcomes
  • vertical transmission

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