TY - JOUR
T1 - Cherenkov luminescence imaging of shallow sources in semitransparent media
AU - Komarov, Sergey
AU - Liu, Yongjian
AU - Tai, Yuan Chuan
N1 - Funding Information:
The authors would like to thank Dr. Dong Zhou of Washington University in St. Louis and Dr. Cathy Cutler from University of Missouri-Research Reactor [now director of the Medical Isotope Research Production and Development group (MIRP) at Brookhaven National Laboratory] for providing 18F and 198Au for the imaging experiments presented in this manuscript. This work was supported in part by the National Center for Research Resources (NCRR) of the National Institutes of Health (NIH), Award #S10RR031625; and in part by the Office of Science (BER), US Department of Energy (DOE), grant DE-SC0005157; and in part by the National Science Foundation, grant NSF-IIA-1430428; and in part by the Mallinckrodt Institute of Radiology (Allotment 10-006). The content is solely the responsibility of the authors and does not represent the official views of the NCRR of NIH, or the BER of DOE.
Publisher Copyright:
© 2019 The Authors.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - We experimentally investigated the Cherenkov luminescence imaging (CLI) of the isotopes with different beta particles energies (64Cu, 18F, 198Au, 32P, and 76Br) in semitransparent biological equivalent media. The main focus of this work is to characterize the CLI when the sources are at the depth comparable with the range of beta particles. The experimental results were compared with Monte Carlo (MC) simulation results to fine tune the simulation parameters to better model the phantom materials. This approach can be applied to estimate the CLI performance for different phantom materials and isotopes. This work also demonstrates some unique properties of high energy beta particles that can be beneficial for CLI, including the possibility to utilize the betas escaped from the object for imaging purposes.
AB - We experimentally investigated the Cherenkov luminescence imaging (CLI) of the isotopes with different beta particles energies (64Cu, 18F, 198Au, 32P, and 76Br) in semitransparent biological equivalent media. The main focus of this work is to characterize the CLI when the sources are at the depth comparable with the range of beta particles. The experimental results were compared with Monte Carlo (MC) simulation results to fine tune the simulation parameters to better model the phantom materials. This approach can be applied to estimate the CLI performance for different phantom materials and isotopes. This work also demonstrates some unique properties of high energy beta particles that can be beneficial for CLI, including the possibility to utilize the betas escaped from the object for imaging purposes.
KW - Cherenkov luminescence imaging
KW - biomedical imaging
KW - nuclear imaging
UR - http://www.scopus.com/inward/record.url?scp=85061119561&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.24.2.026001
DO - 10.1117/1.JBO.24.2.026001
M3 - Article
C2 - 30724042
AN - SCOPUS:85061119561
SN - 1083-3668
VL - 24
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 2
M1 - 026001
ER -