Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis

Dinesh Vyas, Gieric Laput, Arpitak K. Vyas

Research output: Contribution to journalReview articlepeer-review

215 Scopus citations


The lack of therapy and the failure of existing therapy has been a challenge for clinicians in treating various cancers. Doxorubicin, 5-fluorouracil, cisplatin, and paclitaxel are the first-line therapy in various cancers; however, toxicity, resistance, and treatment failure limit their clinical use. Their status leads us to discover and investigate more targeted therapy with more efficacy. In this article, we dissect literature from the patient perspective, the tumor biology perspective, therapy-induced metastasis, and cell data generated in the laboratory.

Original languageEnglish
Pages (from-to)1015-1023
Number of pages9
JournalOncoTargets and Therapy
StatePublished - Jun 12 2014


  • Cancer
  • Chemotherapy
  • Inflammation


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