TY - JOUR
T1 - Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis
AU - Vyas, Dinesh
AU - Laput, Gieric
AU - Vyas, Arpitak K.
PY - 2014/6/12
Y1 - 2014/6/12
N2 - The lack of therapy and the failure of existing therapy has been a challenge for clinicians in treating various cancers. Doxorubicin, 5-fluorouracil, cisplatin, and paclitaxel are the first-line therapy in various cancers; however, toxicity, resistance, and treatment failure limit their clinical use. Their status leads us to discover and investigate more targeted therapy with more efficacy. In this article, we dissect literature from the patient perspective, the tumor biology perspective, therapy-induced metastasis, and cell data generated in the laboratory.
AB - The lack of therapy and the failure of existing therapy has been a challenge for clinicians in treating various cancers. Doxorubicin, 5-fluorouracil, cisplatin, and paclitaxel are the first-line therapy in various cancers; however, toxicity, resistance, and treatment failure limit their clinical use. Their status leads us to discover and investigate more targeted therapy with more efficacy. In this article, we dissect literature from the patient perspective, the tumor biology perspective, therapy-induced metastasis, and cell data generated in the laboratory.
KW - Cancer
KW - Chemotherapy
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=84902530810&partnerID=8YFLogxK
U2 - 10.2147/OTT.S60114
DO - 10.2147/OTT.S60114
M3 - Review article
AN - SCOPUS:84902530810
SN - 1178-6930
VL - 7
SP - 1015
EP - 1023
JO - OncoTargets and Therapy
JF - OncoTargets and Therapy
ER -