TY - JOUR
T1 - Chemoprevention of prostate cancer
AU - Vemana, Goutham
AU - Hamilton, Robert J.
AU - Andriole, Gerald L.
AU - Freedland, Stephen J.
PY - 2014/1
Y1 - 2014/1
N2 - Large prospective randomized trials, such as the Prostate Cancer Prevention Trial (PCPT), Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial, and Selenium and Vitamin E Cancer Prevention Trial (SELECT), have provided practitioners with considerable data regarding methods of treatment and prevention of prostate cancer. The best-studied medications for prevention are 5 alpha-reductase inhibitors. Their efficacy and side effects are well characterized. Other medications, dietary nutrients, and supplements have not been as well studied and generally do not demonstrate efficacy for disease prevention with an acceptable level of evidence.
AB - Large prospective randomized trials, such as the Prostate Cancer Prevention Trial (PCPT), Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial, and Selenium and Vitamin E Cancer Prevention Trial (SELECT), have provided practitioners with considerable data regarding methods of treatment and prevention of prostate cancer. The best-studied medications for prevention are 5 alpha-reductase inhibitors. Their efficacy and side effects are well characterized. Other medications, dietary nutrients, and supplements have not been as well studied and generally do not demonstrate efficacy for disease prevention with an acceptable level of evidence.
KW - 5 alpha-reductase inhibitors
KW - Dutasteride
KW - Finasteride
KW - Primary prevention
KW - Prostate neoplasm
UR - http://www.scopus.com/inward/record.url?scp=84901494493&partnerID=8YFLogxK
U2 - 10.1146/annurev-med-121211-091759
DO - 10.1146/annurev-med-121211-091759
M3 - Article
C2 - 24188663
AN - SCOPUS:84901494493
SN - 0066-4219
VL - 65
SP - 111
EP - 123
JO - Annual review of medicine
JF - Annual review of medicine
ER -