Chemoprevention of prostate cancer

Goutham Vemana, Robert J. Hamilton, Gerald L. Andriole, Stephen J. Freedland

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Large prospective randomized trials, such as the Prostate Cancer Prevention Trial (PCPT), Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial, and Selenium and Vitamin E Cancer Prevention Trial (SELECT), have provided practitioners with considerable data regarding methods of treatment and prevention of prostate cancer. The best-studied medications for prevention are 5 alpha-reductase inhibitors. Their efficacy and side effects are well characterized. Other medications, dietary nutrients, and supplements have not been as well studied and generally do not demonstrate efficacy for disease prevention with an acceptable level of evidence.

Original languageEnglish
Pages (from-to)111-123
Number of pages13
JournalAnnual review of medicine
StatePublished - Jan 2014


  • 5 alpha-reductase inhibitors
  • Dutasteride
  • Finasteride
  • Primary prevention
  • Prostate neoplasm


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