Chemoprevention of lung squamous cell carcinoma in mice by a mixture of chinese herbs

Yian Wang, Zhongqiu Zhang, Joel R. Garbow, Doug J. Rowland, Ronald A. Lubet, Daniel Sit, Francis Law, Ming You

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Antitumor B (ATB) is a Chinese herbal mixture of six plants. Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal and lung cancers. We have recently developed a new mouse model for lung squamous cell carcinomas (SCC). In this study, lung SCC mouse model was characterized using small-animal imaging techniques (magnetic resonance imaging and computed tomography). ATB decreased lung SCC significantly (3.1-fold; P < 0.05) and increased lung hyperplastic lesions by 2.4-fold (P < 0.05). This observation suggests that ATB can block hyperplasia from progression to SCC. ATB tissue distribution was determined using matrine as a marker chemical. We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs.

Original languageEnglish
Pages (from-to)634-640
Number of pages7
JournalCancer Prevention Research
Volume2
Issue number7
DOIs
StatePublished - Jul 1 2009

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