In the struggle for optimal host defense against infection with viruses, two major events are critical: death of the infected host cell and proper immune cell activation at the site of infection. Here we summarize our recent work indicating that chemokines exhibit a distinct capacity to regulate both of these events. We put particular emphasis on a recently completed study indicating that chemokine CCL5 may prevent cell death and thereby preserve innate immune cell function in the setting of viral infection. In addition, we introduce new work to support the more traditional role of CCL5 in mediating adaptive immune cell traffic and activation in this same setting.

Original languageEnglish
Pages (from-to)380-383
Number of pages4
JournalCell Cycle
Issue number4
StatePublished - Feb 16 2006


  • AKT
  • CCL5
  • CCR5
  • ERK
  • Epithelial cell
  • Macrophage
  • PI3K
  • Respiratory viruses


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