Chemogenomics with protein secondary-structure mimetics.

Garland R. Marshall, Daniel J. Kuster, Y. Che

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

During molecular recognition of proteins in biological systems, helices, reverse turns, and beta-sheets are dominant motifs. Often there are therapeutic reasons for blocking such recognition sites, and significant progress has been made by medicinal chemists in the design and synthesis of semirigid molecular scaffolds on which to display amino acid side chains. The basic premise is that preorganization of the competing ligand enhances the binding affinity and potential selectivity of the inhibitor. In this chapter, current progress in these efforts is reviewed.

Original languageEnglish
Pages (from-to)123-158
Number of pages36
JournalMethods in molecular biology (Clifton, N.J.)
Volume575
DOIs
StatePublished - 2009

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