Chemical sensing in development and function of intestinal lymphocytes

Luisa Cervantes-Barragan, Marco Colonna

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

The immune system of the intestinal tract has the challenging task of recognizing and eliminating intestinal pathogens while maintaining tolerance to dietary and commensal antigens; therefore, it must be able to sense environmental cues within the intestine and mount suitable responses dictated by their pathogenic or nonpathogenic nature. The aryl hydrocarbon receptor (AHR) was originally characterized as a chemical sensor of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [12]. More recently, AHR has emerged as a major chemical sensor expressed in many intestinal immune cells that enables them to distinguish nutritional and microbial cues and is, therefore, important for development, maintenance and function of the intestinal immune system. In this review, we will highlight recent advances in our knowledge of the role of AHR signaling in intestinal innate lymphoid cells (ILC), T cells and B cells.

Original languageEnglish
Pages (from-to)112-116
Number of pages5
JournalCurrent Opinion in Immunology
Volume50
DOIs
StatePublished - Feb 2018

Fingerprint

Dive into the research topics of 'Chemical sensing in development and function of intestinal lymphocytes'. Together they form a unique fingerprint.

Cite this