Chemical features of peptide selection by the class II histocompatibility molecules

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Abstract

We have reached the stage where immunogenicity of protein antigens can be defined precisely at a biochemical and cellular level and where important quantitative parameters can be defined. The immunogenicity of T cell epitopes has been particularly difficult to define because of the added complexity resulting from the need for a first step for processing, and peptide interaction with MHC proteins. We have shown in this review some of the advances brought about using HEL as a model protein and the rewards of applying biochemical criteria to antigen presentation. The recent results with I-A(g7), a diabetogenic class II MHC molecule, strongly indicate the complexities of autoimmunity and the urgent need to continue applying biochemical features to explain self-immunization.

Original languageEnglish
Pages (from-to)651-664
Number of pages14
JournalAmerican Journal of Pathology
Volume154
Issue number3
DOIs
StatePublished - Mar 1999

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