TY - JOUR
T1 - Chemical features of peptide selection by the class II histocompatibility molecules
AU - Unanue, Emil R.
N1 - Funding Information:
This paper highlights the work presented at the 1998 meeting of the American Society for Investigative Pathology on the occasion of the Rous-Whipple Award. I thank the National Institute of Allergy and Infectious Diseases of the National Institutes of Health for their support of this research. This work represents the efforts of many colleagues—graduate students, postdoctoral fellows and faculty—to whom I am deeply grateful. The efforts of our recent laboratory members have been cited in the text.
PY - 1999/3
Y1 - 1999/3
N2 - We have reached the stage where immunogenicity of protein antigens can be defined precisely at a biochemical and cellular level and where important quantitative parameters can be defined. The immunogenicity of T cell epitopes has been particularly difficult to define because of the added complexity resulting from the need for a first step for processing, and peptide interaction with MHC proteins. We have shown in this review some of the advances brought about using HEL as a model protein and the rewards of applying biochemical criteria to antigen presentation. The recent results with I-A(g7), a diabetogenic class II MHC molecule, strongly indicate the complexities of autoimmunity and the urgent need to continue applying biochemical features to explain self-immunization.
AB - We have reached the stage where immunogenicity of protein antigens can be defined precisely at a biochemical and cellular level and where important quantitative parameters can be defined. The immunogenicity of T cell epitopes has been particularly difficult to define because of the added complexity resulting from the need for a first step for processing, and peptide interaction with MHC proteins. We have shown in this review some of the advances brought about using HEL as a model protein and the rewards of applying biochemical criteria to antigen presentation. The recent results with I-A(g7), a diabetogenic class II MHC molecule, strongly indicate the complexities of autoimmunity and the urgent need to continue applying biochemical features to explain self-immunization.
UR - http://www.scopus.com/inward/record.url?scp=0032999837&partnerID=8YFLogxK
U2 - 10.1016/S0002-9440(10)65311-4
DO - 10.1016/S0002-9440(10)65311-4
M3 - Article
C2 - 10079241
AN - SCOPUS:0032999837
SN - 0002-9440
VL - 154
SP - 651
EP - 664
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 3
ER -