TY - JOUR
T1 - Chemical and Biological Aspects of Nutritional Immunity—Perspectives for New Anti-Infectives that Target Iron Uptake Systems
AU - Bilitewski, Ursula
AU - Blodgett, Joshua A.V.
AU - Duhme-Klair, Anne Kathrin
AU - Dallavalle, Sabrina
AU - Laschat, Sabine
AU - Routledge, Anne
AU - Schobert, Rainer
N1 - Funding Information:
Generous financial support by the Ministerium für Wissen-schaft, Forschung und Kunst des Landes Baden-Württemberg and the Engineering and Physical Sciences Research Council (EPSRC, grant EP/L024829/1) is gratefully acknowledged. We would like to thank Dr. Angelika Baro for her help during manuscript preparation and Johannes Christian Haenle for the illustrations.
Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2017/11/13
Y1 - 2017/11/13
N2 - Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to “nutritional immunity”. However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance.
AB - Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to “nutritional immunity”. However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance.
KW - antibiotics
KW - heme proteins
KW - iron
KW - nutritional immunity
KW - siderophores
UR - http://www.scopus.com/inward/record.url?scp=85031316646&partnerID=8YFLogxK
U2 - 10.1002/anie.201701586
DO - 10.1002/anie.201701586
M3 - Review article
C2 - 28439959
AN - SCOPUS:85031316646
SN - 1433-7851
VL - 56
SP - 14360
EP - 14382
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 46
ER -