Chelation Therapy for Transfusion-Dependent Adults

Timothy J. Ley, Arthur W. Nienhuis

Research output: Contribution to journalLetterpeer-review

2 Scopus citations

Abstract

To the Editor: Brittenham and colleagues recently described the use of the superconducting quantum-interference-device (SQUID) susceptometer for detecting and quantifying iron stores in the liver.1 In an accompanying editorial,2 Finch asked when physicians should begin chelation therapy for patients who require long-term transfusions. The ultimate pathophysiologic consequences of transfusional and hereditary hemochromatosis are similar,3 despite early differences in the distribution of iron between parenchymal and reticuloendothelial cells. Even patients with hypoproliferative anemia inevitably acquire clinical evidence of iron overload. Buja and Roberts4 found heavy deposition of iron at autopsy in the hearts of adult patients who had received more than.

Original languageEnglish
Pages (from-to)1422-1423
Number of pages2
JournalNew England Journal of Medicine
Volume308
Issue number23
DOIs
StatePublished - Jun 9 1983

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