Checkpoint Inhibitors in Kidney Transplant Recipients and the Potential Risk of Rejection

Mohamed M. Ibrahim; Tarek Alhamad

doi:10.1007/978-3-031-13569-9_36

Checkpoint Inhibitors in Kidney Transplant Recipients and the Potential Risk of Rejection

Mohamed M. Ibrahim, Tarek Alhamad

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The immune system utilizes checkpoints to maintain self-tolerance or to prevent collateral tissue damage during an immune response. The immune system recognizes and eliminates cancer cells; however, cancers can develop multiple strategies to suppress this immune response. Cancers can alter the normal control mechanisms used to enforce peripheral self-tolerance, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA4)-mediated suppression by regulatory T cells. They can also mitigate chronic inflammation through programmed cell death protein-1 (PD1)-mediated exhaustion of antitumor cytotoxic T lymphocytes.

Original language	English
Title of host publication	Complications in Kidney Transplantation
Subtitle of host publication	A Case-Based Guide to Management
Publisher	Springer International Publishing
Pages	225-230
Number of pages	6
ISBN (Electronic)	9783031135699
ISBN (Print)	9783031135682
DOIs	https://doi.org/10.1007/978-3-031-13569-9_36
State	Published - Jan 1 2022

Keywords

Allograft rejection
Checkpoint inhibitors
Kidney transplantation

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10.1007/978-3-031-13569-9_36

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Checkpoint Inhibitors in Kidney Transplant Recipients and the Potential Risk of Rejection

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Keywords

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