Checkpoint control of mitotic exit - Do budding yeast mind the GAP?

John A. Cooper, Scott A. Nelson

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Cell cycle checkpoints can delay mitotic exit in budding yeast. The master controller is the small GTPase Tem1, with inputs from a proposed guanine nucleotide exchange factor (GEF), Lte1, and a GTPase-activating protein (GAP), Bub2/Bfa1. In this issue, Fraschini et al. (p. 335) show that GAP activity of Bub2/Bfa1 appears to be dispensable for inactivation of Tem1 in cells. Their results call into question the GTP/GDP switch model for Tem1 activity, as have other results in the past. The paper also focuses attention on the two spindle pole bodies as potential sites for regulation of Tem1.

Original languageEnglish
Pages (from-to)331-333
Number of pages3
JournalJournal of Cell Biology
Issue number3
StatePublished - Jan 30 2006


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