TY - JOUR
T1 - Charge-remote fragmentations
T2 - method, mechanism and applications
AU - Gross, Michael L.
N1 - Funding Information:
This review was prepared with support of the U.S. National Science Foundation (Grant CHE 9017250). The author is indebted to J. Adams, K. Biemann, R. Boyd, C. Fenselau, N. Jensen, J. McCloskey, R. Murphy, J.-C. Prom6, M. Siegel, K. Tomer, A. Tuinman, J. Watson and V. Wysocki for providing reprints. The author thanks K. Tomer for bringing ref. 7 to his attention.
PY - 1992/9/2
Y1 - 1992/9/2
N2 - Charge-remote fragmentations are viewed as both a class of gas-phase ion decomposition reactions and as a method or approach to determining structures of biomolecules, surfactants and other lipophilic materials. Although they were first identified as decompositions of fatty acids, the processes are found in the fragmentations of steroids, prostaglandins, complex lipids, peptides, carbohydrates and certain anti-biotics. This article is a review of the subject, emphasizing material published since 1988. It covers research focused on both expanding the scope of charge-remote fragmentation and applying it to real problems. Questions on the details of mechanism and energetics are also addressed. The 1,4-elimination of H2 is still the favored mechanism of the cleavage of C@C bonds in saturated alkyl chains, but there are alternatives that deserve consideration.
AB - Charge-remote fragmentations are viewed as both a class of gas-phase ion decomposition reactions and as a method or approach to determining structures of biomolecules, surfactants and other lipophilic materials. Although they were first identified as decompositions of fatty acids, the processes are found in the fragmentations of steroids, prostaglandins, complex lipids, peptides, carbohydrates and certain anti-biotics. This article is a review of the subject, emphasizing material published since 1988. It covers research focused on both expanding the scope of charge-remote fragmentation and applying it to real problems. Questions on the details of mechanism and energetics are also addressed. The 1,4-elimination of H2 is still the favored mechanism of the cleavage of C@C bonds in saturated alkyl chains, but there are alternatives that deserve consideration.
UR - http://www.scopus.com/inward/record.url?scp=44049112946&partnerID=8YFLogxK
U2 - 10.1016/0168-1176(92)85060-D
DO - 10.1016/0168-1176(92)85060-D
M3 - Article
AN - SCOPUS:44049112946
SN - 0168-1176
VL - 118-119
SP - 137
EP - 165
JO - International Journal of Mass Spectrometry and Ion Processes
JF - International Journal of Mass Spectrometry and Ion Processes
IS - C
ER -