Characterizing the chromosomes of the platypus (Ornithorhynchus anatinus)

Daniel McMillan, Pat Miethke, Amber E. Alsop, Willem Rens, Patricia O'Brien, Vladimir Trifonov, Frederic Veyrunes, Kyriena Schatzkamer, Colin L. Kremitzki, Tina Graves, Wesley Warren, Frank Grützner, Malcolm A. Ferguson-Smith, Jennifer A.Marshall Graves

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Like the unique platypus itself, the platypus genome is extraordinary because of its complex sex chromosome system, and is controversial because of difficulties in identification of small autosomes and sex chromosomes. A 6-fold shotgun sequence of the platypus genome is now available and is being assembled with the help of physical mapping. It is therefore essential to characterize the chromosomes and resolve the ambiguities and inconsistencies in identifying autosomes and sex chromosomes. We have used chromosome paints and DAPI banding to identify and classify pairs of autosomes and sex chromosomes. We have established an agreed nomenclature and identified anchor BAC clones for each chromosome that will ensure unambiguous gene localizations.

Original languageEnglish
Pages (from-to)961-974
Number of pages14
JournalChromosome Research
Volume15
Issue number8
DOIs
StatePublished - Dec 1 2007

Keywords

  • Chromosome painting
  • Karyology
  • Ornithorhynchus anatinus
  • Platypus
  • Sex chromosomes

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    McMillan, D., Miethke, P., Alsop, A. E., Rens, W., O'Brien, P., Trifonov, V., Veyrunes, F., Schatzkamer, K., Kremitzki, C. L., Graves, T., Warren, W., Grützner, F., Ferguson-Smith, M. A., & Graves, J. A. M. (2007). Characterizing the chromosomes of the platypus (Ornithorhynchus anatinus). Chromosome Research, 15(8), 961-974. https://doi.org/10.1007/s10577-007-1186-2