Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy

Farnoush Forghani; Taylor Patton; Jennifer Kwak; David Thomas; Quentin Diot; Chad Rusthoven; Richard Castillo; Edward Castillo; Inga Grills; Thomas Guerrero; Moyed Miften; Yevgeniy Vinogradskiy

doi:10.1016/j.radonc.2021.04.022

Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy

Farnoush Forghani, Taylor Patton, Jennifer Kwak, David Thomas, Quentin Diot, Chad Rusthoven, Richard Castillo, Edward Castillo, Inga Grills, Thomas Guerrero, Moyed Miften, Yevgeniy Vinogradskiy

Division of Medical Physics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

This study investigates agreement between ventilation and perfusion for lung cancer patients undergoing radiotherapy. Ventilation-perfusion scans of nineteen patients with stage III lung cancer from a prospective protocol were compared using voxel-wise Spearman correlation-coefficients. The presented results show in about 25% of patients, ventilation and perfusion exhibit lower agreement.

Original language	English
Pages (from-to)	120-124
Number of pages	5
Journal	Radiotherapy and Oncology
Volume	160
DOIs	https://doi.org/10.1016/j.radonc.2021.04.022
State	Published - Jul 2021

Keywords

4DCT scans
Dice Similarity
Functional avoidance
Lung cancer
SPECT ventilation/perfusion
Spearman correlation

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10.1016/j.radonc.2021.04.022

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Forghani, F., Patton, T., Kwak, J., Thomas, D., Diot, Q., Rusthoven, C., Castillo, R., Castillo, E., Grills, I., Guerrero, T., Miften, M., & Vinogradskiy, Y. (2021). Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy. Radiotherapy and Oncology, 160, 120-124. https://doi.org/10.1016/j.radonc.2021.04.022

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title = "Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy",

abstract = "This study investigates agreement between ventilation and perfusion for lung cancer patients undergoing radiotherapy. Ventilation-perfusion scans of nineteen patients with stage III lung cancer from a prospective protocol were compared using voxel-wise Spearman correlation-coefficients. The presented results show in about 25% of patients, ventilation and perfusion exhibit lower agreement.",

keywords = "4DCT scans, Dice Similarity, Functional avoidance, Lung cancer, SPECT ventilation/perfusion, Spearman correlation",

author = "Farnoush Forghani and Taylor Patton and Jennifer Kwak and David Thomas and Quentin Diot and Chad Rusthoven and Richard Castillo and Edward Castillo and Inga Grills and Thomas Guerrero and Moyed Miften and Yevgeniy Vinogradskiy",

note = "Funding Information: This work was funded by NIH Grant R01CA236857 . Funding Information: This work was funded by Grant R01CA236857. Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = jul,

doi = "10.1016/j.radonc.2021.04.022",

language = "English",

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Forghani, F, Patton, T, Kwak, J, Thomas, D, Diot, Q, Rusthoven, C, Castillo, R, Castillo, E, Grills, I, Guerrero, T, Miften, M & Vinogradskiy, Y 2021, 'Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy', Radiotherapy and Oncology, vol. 160, pp. 120-124. https://doi.org/10.1016/j.radonc.2021.04.022

TY - JOUR

T1 - Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy

AU - Forghani, Farnoush

AU - Patton, Taylor

AU - Kwak, Jennifer

AU - Thomas, David

AU - Diot, Quentin

AU - Rusthoven, Chad

AU - Castillo, Richard

AU - Castillo, Edward

AU - Grills, Inga

AU - Guerrero, Thomas

AU - Miften, Moyed

AU - Vinogradskiy, Yevgeniy

PY - 2021/7

Y1 - 2021/7

N2 - This study investigates agreement between ventilation and perfusion for lung cancer patients undergoing radiotherapy. Ventilation-perfusion scans of nineteen patients with stage III lung cancer from a prospective protocol were compared using voxel-wise Spearman correlation-coefficients. The presented results show in about 25% of patients, ventilation and perfusion exhibit lower agreement.

AB - This study investigates agreement between ventilation and perfusion for lung cancer patients undergoing radiotherapy. Ventilation-perfusion scans of nineteen patients with stage III lung cancer from a prospective protocol were compared using voxel-wise Spearman correlation-coefficients. The presented results show in about 25% of patients, ventilation and perfusion exhibit lower agreement.

KW - 4DCT scans

KW - Dice Similarity

KW - Functional avoidance

KW - Lung cancer

KW - SPECT ventilation/perfusion

KW - Spearman correlation

UR - http://www.scopus.com/inward/record.url?scp=85106294413&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2021.04.022

DO - 10.1016/j.radonc.2021.04.022

M3 - Article

C2 - 33964328

AN - SCOPUS:85106294413

SN - 0167-8140

VL - 160

SP - 120

EP - 124

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

ER -

Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy

Abstract

Keywords

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