TY - JOUR
T1 - Characterizing Alcohol Expectancies in the ABCD Study
T2 - Associations with Sociodemographic Factors, the Immediate Social Environment, and Genetic Propensities
AU - Johnson, Emma C.
AU - Paul, Sarah E.
AU - Baranger, David A.A.
AU - Hatoum, Alexander S.
AU - Colbert, Sarah M.C.
AU - Lin, Shuyu
AU - Wolff, Rachel
AU - Gorelik, Aaron J.
AU - Hansen, Isabella
AU - Karcher, Nicole R.
AU - Bogdan, Ryan
AU - Agrawal, Arpana
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/5
Y1 - 2023/5
N2 - Alcohol expectancies (AEs) are associated with likelihood of alcohol initiation and subsequent alcohol use disorders. It is unclear whether genetic predisposition to alcohol use and/or related traits contributes to shaping how one expects to feel when drinking alcohol. We used the Adolescent Brain Cognitive Development study to examine associations between genetic propensities (i.e., polygenic risk for problematic alcohol use, depression, risk-taking), sociodemographic factors (i.e., parent income), and the immediate social environment (i.e., peer use and disapproval toward alcohol) and positive and negative AEs in alcohol-naïve children (max analytic N = 5,352). Mixed-effect regression models showed that age, parental education, importance of the child’s religious beliefs, adverse childhood experiences, and peer disapproval of alcohol use were associated with positive and/or negative AEs, to varying degrees. Overall, our results suggest several familial and psychosocial predictors of AEs but little evidence of contributions from polygenic liability to problematic alcohol use or related phenotypes.
AB - Alcohol expectancies (AEs) are associated with likelihood of alcohol initiation and subsequent alcohol use disorders. It is unclear whether genetic predisposition to alcohol use and/or related traits contributes to shaping how one expects to feel when drinking alcohol. We used the Adolescent Brain Cognitive Development study to examine associations between genetic propensities (i.e., polygenic risk for problematic alcohol use, depression, risk-taking), sociodemographic factors (i.e., parent income), and the immediate social environment (i.e., peer use and disapproval toward alcohol) and positive and negative AEs in alcohol-naïve children (max analytic N = 5,352). Mixed-effect regression models showed that age, parental education, importance of the child’s religious beliefs, adverse childhood experiences, and peer disapproval of alcohol use were associated with positive and/or negative AEs, to varying degrees. Overall, our results suggest several familial and psychosocial predictors of AEs but little evidence of contributions from polygenic liability to problematic alcohol use or related phenotypes.
KW - Adverse childhood experiences
KW - Alcohol expectancies
KW - Educational attainment
KW - Peer deviance
KW - Polygenic risk scores
KW - Religiosity
UR - http://www.scopus.com/inward/record.url?scp=85146567692&partnerID=8YFLogxK
U2 - 10.1007/s10519-023-10133-2
DO - 10.1007/s10519-023-10133-2
M3 - Article
C2 - 36662388
AN - SCOPUS:85146567692
SN - 0001-8244
VL - 53
SP - 265
EP - 278
JO - Behavior genetics
JF - Behavior genetics
IS - 3
ER -