Characterizing 5-methylcytosine in the mammalian epitranscriptome

Shobbir Hussain, Jelena Aleksic, Sandra Blanco, Sabine Dietmann, Michaela Frye

Research output: Contribution to journalArticlepeer-review

174 Scopus citations


The post-transcriptional modification 5-methylcytosine (m5C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m5C RNA methylome. We also discuss the potential functions of m5C in RNA and compare them to 6-methyladenosine modifications.

Original languageEnglish
Article number215
JournalGenome biology
Issue number11
StatePublished - Nov 29 2013


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