Characterizing 5-methylcytosine in the mammalian epitranscriptome

Shobbir Hussain; Jelena Aleksic; Sandra Blanco; Sabine Dietmann; Michaela Frye

doi:10.1186/gb4143

Characterizing 5-methylcytosine in the mammalian epitranscriptome

Shobbir Hussain, Jelena Aleksic, Sandra Blanco, Sabine Dietmann, Michaela Frye

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182 Scopus citations

Abstract

The post-transcriptional modification 5-methylcytosine (m⁵C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m⁵C RNA methylome. We also discuss the potential functions of m⁵C in RNA and compare them to 6-methyladenosine modifications.

Original language	English
Article number	215
Journal	Genome biology
Volume	14
Issue number	11
DOIs	https://doi.org/10.1186/gb4143
State	Published - Nov 29 2013

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title = "Characterizing 5-methylcytosine in the mammalian epitranscriptome",

abstract = "The post-transcriptional modification 5-methylcytosine (m5C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m5C RNA methylome. We also discuss the potential functions of m5C in RNA and compare them to 6-methyladenosine modifications.",

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AU - Hussain, Shobbir

AU - Aleksic, Jelena

AU - Blanco, Sandra

AU - Dietmann, Sabine

AU - Frye, Michaela

PY - 2013/11/29

Y1 - 2013/11/29

N2 - The post-transcriptional modification 5-methylcytosine (m5C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m5C RNA methylome. We also discuss the potential functions of m5C in RNA and compare them to 6-methyladenosine modifications.

AB - The post-transcriptional modification 5-methylcytosine (m5C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m5C RNA methylome. We also discuss the potential functions of m5C in RNA and compare them to 6-methyladenosine modifications.

UR - http://www.scopus.com/inward/record.url?scp=84888791449&partnerID=8YFLogxK

U2 - 10.1186/gb4143

DO - 10.1186/gb4143

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SN - 1474-7596

VL - 14

JO - Genome biology

JF - Genome biology

IS - 11

M1 - 215

ER -

Characterizing 5-methylcytosine in the mammalian epitranscriptome

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