Characterization of the calcaneal fat pad in diabetic and non-diabetic patients using magnetic resonance imaging

Patricia F. Kao; Brian L. Davis; Peter A. Hardy

doi:10.1016/S0730-725X(99)00019-3

Characterization of the calcaneal fat pad in diabetic and non-diabetic patients using magnetic resonance imaging

Patricia F. Kao, Brian L. Davis, Peter A. Hardy

Division of Nephrology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

It is well known that diabetic patients have a high incidence of foot ulceration. The purpose of this study was to determine whether magnetic resonance (MR) imaging can detect changes in the composition of the calcaneal fat pad in diabetic feet. MR data were collected in vitro from amputated specimens (eight from diabetic patients and eight from non-diabetic patients) as well as in vivo from age-matched diabetic and control subjects (four subjects each group.) Three types of images were acquired: spin lattice (T₁), spin-spin (T₂), and magnetization transfer (M(T)). The in vitro results showed statistically significant differences in the T₁, T₂, and MT parameters between the two disease groups. The same trends were shown in the study of live subjects but the differences were not statistically significant. The differences are believed to arise from changes in the composition of the tissues as a result of the progression of diabetes.

Original language	English
Pages (from-to)	851-857
Number of pages	7
Journal	Magnetic Resonance Imaging
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/S0730-725X(99)00019-3
State	Published - Jul 1999

Keywords

Diabetes complications
Fat pad
Foot ulceration
Image processing

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10.1016/S0730-725X(99)00019-3

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title = "Characterization of the calcaneal fat pad in diabetic and non-diabetic patients using magnetic resonance imaging",

abstract = "It is well known that diabetic patients have a high incidence of foot ulceration. The purpose of this study was to determine whether magnetic resonance (MR) imaging can detect changes in the composition of the calcaneal fat pad in diabetic feet. MR data were collected in vitro from amputated specimens (eight from diabetic patients and eight from non-diabetic patients) as well as in vivo from age-matched diabetic and control subjects (four subjects each group.) Three types of images were acquired: spin lattice (T1), spin-spin (T2), and magnetization transfer (M(T)). The in vitro results showed statistically significant differences in the T1, T2, and MT parameters between the two disease groups. The same trends were shown in the study of live subjects but the differences were not statistically significant. The differences are believed to arise from changes in the composition of the tissues as a result of the progression of diabetes.",

keywords = "Diabetes complications, Fat pad, Foot ulceration, Image processing",

author = "Kao, {Patricia F.} and Davis, {Brian L.} and Hardy, {Peter A.}",

note = "Funding Information: This work was supported by a Basic Science Grant from The Whitaker Foundation. Funding Information: The authors are indebted to Dominik Meier of the Department of Biomedical Engineering for the use of his software tool ISAC, which enabled the generation of histograms of image intensity and to Dr. Amrik Shah who performed statistical analyses of the data. This work was supported by a grant from the Whitaker Foundation.",

year = "1999",

month = jul,

doi = "10.1016/S0730-725X(99)00019-3",

language = "English",

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pages = "851--857",

journal = "Magnetic Resonance Imaging",

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T1 - Characterization of the calcaneal fat pad in diabetic and non-diabetic patients using magnetic resonance imaging

AU - Kao, Patricia F.

AU - Davis, Brian L.

AU - Hardy, Peter A.

N1 - Funding Information: This work was supported by a Basic Science Grant from The Whitaker Foundation. Funding Information: The authors are indebted to Dominik Meier of the Department of Biomedical Engineering for the use of his software tool ISAC, which enabled the generation of histograms of image intensity and to Dr. Amrik Shah who performed statistical analyses of the data. This work was supported by a grant from the Whitaker Foundation.

PY - 1999/7

Y1 - 1999/7

N2 - It is well known that diabetic patients have a high incidence of foot ulceration. The purpose of this study was to determine whether magnetic resonance (MR) imaging can detect changes in the composition of the calcaneal fat pad in diabetic feet. MR data were collected in vitro from amputated specimens (eight from diabetic patients and eight from non-diabetic patients) as well as in vivo from age-matched diabetic and control subjects (four subjects each group.) Three types of images were acquired: spin lattice (T1), spin-spin (T2), and magnetization transfer (M(T)). The in vitro results showed statistically significant differences in the T1, T2, and MT parameters between the two disease groups. The same trends were shown in the study of live subjects but the differences were not statistically significant. The differences are believed to arise from changes in the composition of the tissues as a result of the progression of diabetes.

AB - It is well known that diabetic patients have a high incidence of foot ulceration. The purpose of this study was to determine whether magnetic resonance (MR) imaging can detect changes in the composition of the calcaneal fat pad in diabetic feet. MR data were collected in vitro from amputated specimens (eight from diabetic patients and eight from non-diabetic patients) as well as in vivo from age-matched diabetic and control subjects (four subjects each group.) Three types of images were acquired: spin lattice (T1), spin-spin (T2), and magnetization transfer (M(T)). The in vitro results showed statistically significant differences in the T1, T2, and MT parameters between the two disease groups. The same trends were shown in the study of live subjects but the differences were not statistically significant. The differences are believed to arise from changes in the composition of the tissues as a result of the progression of diabetes.

KW - Diabetes complications

KW - Fat pad

KW - Foot ulceration

KW - Image processing

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DO - 10.1016/S0730-725X(99)00019-3

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AN - SCOPUS:0032985465

SN - 0730-725X

VL - 17

SP - 851

EP - 857

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 6

ER -

Characterization of the calcaneal fat pad in diabetic and non-diabetic patients using magnetic resonance imaging

Abstract

Keywords

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