Characterization of suppressor T cells induced with the thymus-independent antigen polyvinylpyrrolidone coupled to syngeneic cells

Victoria Fraser, Helen Braley-Mullen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

CAF1 mice injected iv with polyvinylpyrrolidone (PVP) coupled to syngeneic spleen cells (PVP-SC) and challenged several days later with 0.25 μg PVP produced fewer PVP-specific IgM plague-forming cells (PFC) than mice injected with Mock-SC. Both 10,000 and 360,000 MW PVP could induce unresponsiveness after coupling to SC. The unresponsiveness induced by PVP-SC was shown to be mediated, at least in part, by antigen-specific suppressor T cells (TS). The PVP-specific TS were I-J positive and belonged to the Lyt 1+ 2+ subset of T cells. The Ts precursors were sensitive to 20 mg/kg cyclophosphamide (Cy) and to antilymphocyte serum (ALS). Kinetics studies suggested that unresponsiveness induced by PVP-SC may be of two types since unresponsiveness in the intact animal appeared earlier and did not last as long as detectable TS activity.

Original languageEnglish
Pages (from-to)177-187
Number of pages11
JournalCellular Immunology
Volume63
Issue number1
DOIs
StatePublished - Sep 1 1981

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