Characterization of sites of tyrosine sulfation in proteins and criteria for predicting their occurrence

Glen Hortin, Rodney Folz, Jeffrey I. Gordon, Arnold W. Strauss

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

A wide variety of secretory proteins have recently been found to undergo post-translational sulfation of specific tyrosine residues. Here, amino acid sequences surrounding known sulfation sites in proteins are analyzed in order to identify factors which determine the specificity of sulfation. Several distinctive features of sulfation sites are identified, including: 1) abundance of acidic amino acid residues, 2) lack of basic residues, 3) low hydropathy, 4) absence of neighboring cysteine residues, 5) lack of extended secondary structure. Rules are proposed for predicting likely sites of sulfation based on the amino acid sequence of a protein.

Original languageEnglish
Pages (from-to)326-333
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume141
Issue number1
DOIs
StatePublished - Nov 26 1986

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