Characterization of rare-earth-doped nanophosphors for photodynamic therapy excited by clinical ionizing radiation beams

Arash Darafsheh, Stan Najmr, Taejong Paik, Michael E. Tenuto, Christopher B. Murray, Jarod C. Finlay, Joseph S. Friedberg

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

18 Scopus citations

Abstract

We investigated the optical properties of novel terbium (Tb3+)-doped nanophosphors with various host compounds irradiated by clinical electron, photon, and proton beams for their potential as optical probes. The emission spectra of nanophosphors embedded in tissue-mimicking phantoms were collected by an optical fiber connected to a CCD-coupled spectrograph while the samples were irradiated with electron and photon beams generated by a medical linear accelerator and proton beams generated by a clinical cyclotron. We characterized the luminescence of such nanophosphors as a function of the beam energy and observed a dose dependency of the luminescence signal. We demonstrated X-ray luminescence, cathodoluminescence, and ionoluminescence of the nanophosphors in clinical ionizing radiation fields, which indicates their potential as downconverters of high-energy radiation into visible light.

Original languageEnglish
Title of host publicationOptical Methods for Tumor Treatment and Detection
Subtitle of host publicationMechanisms and Techniques in Photodynamic Therapy XXIV
EditorsDavid H. Kessel, Tayyaba Hasan
PublisherSPIE
ISBN (Electronic)9781628413984
DOIs
StatePublished - 2015
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV - San Francisco, United States
Duration: Feb 7 2015Feb 9 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9308
ISSN (Print)1605-7422

Conference

ConferenceOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV
Country/TerritoryUnited States
CitySan Francisco
Period02/7/1502/9/15

Keywords

  • Nanocrystal
  • dosimetry
  • ionizing radiation
  • nanophosphor
  • photodynamic therapy.
  • terbium

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