We investigated the optical properties of novel terbium (Tb3+)-doped nanophosphors with various host compounds irradiated by clinical electron, photon, and proton beams for their potential as optical probes. The emission spectra of nanophosphors embedded in tissue-mimicking phantoms were collected by an optical fiber connected to a CCD-coupled spectrograph while the samples were irradiated with electron and photon beams generated by a medical linear accelerator and proton beams generated by a clinical cyclotron. We characterized the luminescence of such nanophosphors as a function of the beam energy and observed a dose dependency of the luminescence signal. We demonstrated X-ray luminescence, cathodoluminescence, and ionoluminescence of the nanophosphors in clinical ionizing radiation fields, which indicates their potential as downconverters of high-energy radiation into visible light.
|Title of host publication||Optical Methods for Tumor Treatment and Detection|
|Subtitle of host publication||Mechanisms and Techniques in Photodynamic Therapy XXIV|
|Editors||David H. Kessel, Tayyaba Hasan|
|State||Published - 2015|
|Event||Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV - San Francisco, United States|
Duration: Feb 7 2015 → Feb 9 2015
|Name||Progress in Biomedical Optics and Imaging - Proceedings of SPIE|
|Conference||Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV|
|Period||02/7/15 → 02/9/15|
- ionizing radiation
- photodynamic therapy.