Characterization of NADPH diaphorase activity in rat sympathetic autonomic ganglia-effect of diabetes and aging

Robert E. Schmidt; Denise A. Dorsey; Michael L. McDaniel; John A. Corbett

doi:10.1016/0006-8993(93)91103-Y

Characterization of NADPH diaphorase activity in rat sympathetic autonomic ganglia-effect of diabetes and aging

Robert E. Schmidt
, Denise A. Dorsey
, Michael L. McDaniel
, John A. Corbett

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

NADPH-diaphorase histochemistry, which identifies neural sites of nitric oxide production, demonstrated intensely stained nerve terminals surrounding the cell bodies of a subpopulation of neurons in rat prevertebral celiac and superior mesenteric sympathetic ganglia but failed to comparably label terminals in paravertebral superior cervical ganglia or perikarya in any sympathetic ganglion. The superior mesenteric ganglia of aged and diabetic rats, in which synaptic dysplasia (neuroaxonal dystrophy) is prominent, failed to show involvement of diaphorase containing nerve terminals.

Original language	English
Pages (from-to)	343-348
Number of pages	6
Journal	Brain Research
Volume	617
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(93)91103-Y
State	Published - Jul 23 1993

Keywords

Aging
Diabetes
Diaphorase
Neuroaxonal dystrophy
Nitric oxide
Sympathetic

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10.1016/0006-8993(93)91103-Y

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title = "Characterization of NADPH diaphorase activity in rat sympathetic autonomic ganglia-effect of diabetes and aging",

abstract = "NADPH-diaphorase histochemistry, which identifies neural sites of nitric oxide production, demonstrated intensely stained nerve terminals surrounding the cell bodies of a subpopulation of neurons in rat prevertebral celiac and superior mesenteric sympathetic ganglia but failed to comparably label terminals in paravertebral superior cervical ganglia or perikarya in any sympathetic ganglion. The superior mesenteric ganglia of aged and diabetic rats, in which synaptic dysplasia (neuroaxonal dystrophy) is prominent, failed to show involvement of diaphorase containing nerve terminals.",

keywords = "Aging, Diabetes, Diaphorase, Neuroaxonal dystrophy, Nitric oxide, Sympathetic",

author = "Schmidt, \{Robert E.\} and Dorsey, \{Denise A.\} and McDaniel, \{Michael L.\} and Corbett, \{John A.\}",

note = "Funding Information: This work was supported by NIH Grants DK 19645, DKO6181 and AG 10299. We would like to thank Karen Erickson for secretarial assistance.",

year = "1993",

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doi = "10.1016/0006-8993(93)91103-Y",

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T1 - Characterization of NADPH diaphorase activity in rat sympathetic autonomic ganglia-effect of diabetes and aging

AU - Schmidt, Robert E.

AU - Dorsey, Denise A.

AU - McDaniel, Michael L.

AU - Corbett, John A.

N1 - Funding Information: This work was supported by NIH Grants DK 19645, DKO6181 and AG 10299. We would like to thank Karen Erickson for secretarial assistance.

PY - 1993/7/23

Y1 - 1993/7/23

N2 - NADPH-diaphorase histochemistry, which identifies neural sites of nitric oxide production, demonstrated intensely stained nerve terminals surrounding the cell bodies of a subpopulation of neurons in rat prevertebral celiac and superior mesenteric sympathetic ganglia but failed to comparably label terminals in paravertebral superior cervical ganglia or perikarya in any sympathetic ganglion. The superior mesenteric ganglia of aged and diabetic rats, in which synaptic dysplasia (neuroaxonal dystrophy) is prominent, failed to show involvement of diaphorase containing nerve terminals.

AB - NADPH-diaphorase histochemistry, which identifies neural sites of nitric oxide production, demonstrated intensely stained nerve terminals surrounding the cell bodies of a subpopulation of neurons in rat prevertebral celiac and superior mesenteric sympathetic ganglia but failed to comparably label terminals in paravertebral superior cervical ganglia or perikarya in any sympathetic ganglion. The superior mesenteric ganglia of aged and diabetic rats, in which synaptic dysplasia (neuroaxonal dystrophy) is prominent, failed to show involvement of diaphorase containing nerve terminals.

KW - Aging

KW - Diabetes

KW - Diaphorase

KW - Neuroaxonal dystrophy

KW - Nitric oxide

KW - Sympathetic

UR - https://www.scopus.com/pages/publications/0027183822

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DO - 10.1016/0006-8993(93)91103-Y

M3 - Article

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AN - SCOPUS:0027183822

SN - 0006-8993

VL - 617

SP - 343

EP - 348

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Characterization of NADPH diaphorase activity in rat sympathetic autonomic ganglia-effect of diabetes and aging

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