Characterization of murine glioma by magnetic resonance elastography: Preliminary results

Erik H. Clayton, John A. Engelbach, Joel R. Garbow, Philip V. Bayly

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Magnetic resonance elastography (MRE) is a non-invasive imaging technique that permits quantitative measurement of the mechanical properties of biological tissue. In MRE, coherent tissue displacements are induced by a mechanical actuator and images are collected in synchrony with these mechanical motions. Components of displacement in any direction can be measured by applying the motion-encoding gradients along that direction. The mechanical properties of tissue are derived by fitting measured displacement data to the equations governing wave propagation. A number of groups have explored the diagnostic value of MRE in the clinical setting, driven largely by the empirically observed relationship between tissue health and stiffness. The investigation of MRI methods as biomarkers of tumor progression and early therapeutic response remains an extremely active and important area of research. In this regard, MRE has considerable potential for staging cancer and monitoring the effects of therapy. We seek to demonstrate the utility of MRE for cancer staging by tracking the viscoelastic properties of brain tumor in a mouse model of high-grade glioma. Brain tissue viscoelasticity cannot be probed in vivo by any other known imaging technique, yet is suspected to contain valuable information about tissue health. Preliminary results indicate elastographic sensitivity to the presence of brain tumors in the living mouse.

Original languageEnglish
Title of host publicationMechanics of Biological Systems and Materials - Proceedings of the 2012 Annual Conference on Experimental and Applied Mechanics
Pages93-98
Number of pages6
DOIs
StatePublished - Jan 1 2013
Event2012 Annual Conference on Experimental and Applied Mechanics - Costa Mesa, CA, United States
Duration: Jun 11 2012Jun 14 2012

Publication series

NameConference Proceedings of the Society for Experimental Mechanics Series
Volume5
ISSN (Print)2191-5644
ISSN (Electronic)2191-5652

Conference

Conference2012 Annual Conference on Experimental and Applied Mechanics
CountryUnited States
CityCosta Mesa, CA
Period06/11/1206/14/12

Keywords

  • Brain
  • MR imaging
  • Material
  • Mechanical properties
  • Non invasive
  • Tumor

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  • Cite this

    Clayton, E. H., Engelbach, J. A., Garbow, J. R., & Bayly, P. V. (2013). Characterization of murine glioma by magnetic resonance elastography: Preliminary results. In Mechanics of Biological Systems and Materials - Proceedings of the 2012 Annual Conference on Experimental and Applied Mechanics (pp. 93-98). (Conference Proceedings of the Society for Experimental Mechanics Series; Vol. 5). https://doi.org/10.1007/978-1-4614-4427-5_14