Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy

Christine M. O'Brien; Elizabeth Vargis; Chris Slaughter; Amy P. Rudin; Jennifer L. Herington; Kelly A. Bennett; Jeff Reese; Anita Mahadevan-Jansen

doi:10.1117/12.2077775

Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy

Christine M. O'Brien
, Elizabeth Vargis
, Chris Slaughter
, Amy P. Rudin
, Jennifer L. Herington
, Kelly A. Bennett
, Jeff Reese
, Anita Mahadevan-Jansen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Abstract

Globally, fifteen million babies are born preterm each year, affecting 1 in 8 pregnancies in the US alone. Cervical remodeling includes a biochemical cascade of changes that ultimately result in the thinning and dilation of the cervix for passage of a fetus. This process is poorly understood and is the focus of this study. Our group is utilizing Raman spectroscopy to evaluate biochemical changes occurring in the human cervix throughout pregnancy. This technique has high molecular specificity and can be performed in vivo, with the potential to unveil new molecular dynamics essential for cervical remodeling.

Original language	English
Title of host publication	Photonic Therapeutics and Diagnostics XI
Editors	Hyun Wook Kang, Justus F. Ilgner, Melissa C. Skala, Laura Marcu, Haishan Zeng, Mark W. Dewhirst, Kenton W. Gregory, Andreas Mandelis, Bernard Choi, Brian Jet-Fei Wong, Claus-Peter Richter, Guillermo J. Tearney, Alfred Nuttal, Nikiforos Kollias
Publisher	SPIE
ISBN (Electronic)	9781628413939
DOIs	https://doi.org/10.1117/12.2077775
State	Published - 2015
Event	Photonic Therapeutics and Diagnostics XI - San Francisco, United States Duration: Feb 7 2015 → Feb 8 2015

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9303
ISSN (Print)	1605-7422

Conference

Conference	Photonic Therapeutics and Diagnostics XI
Country/Territory	United States
City	San Francisco
Period	02/7/15 → 02/8/15

Keywords

Cervix
In vivo
Pregnancy
Raman spectroscopy
Remodeling

Access to Document

10.1117/12.2077775

Cite this

O'Brien, C. M., Vargis, E., Slaughter, C., Rudin, A. P., Herington, J. L., Bennett, K. A., Reese, J., & Mahadevan-Jansen, A. (2015). Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy. In H. W. Kang, J. F. Ilgner, M. C. Skala, L. Marcu, H. Zeng, M. W. Dewhirst, K. W. Gregory, A. Mandelis, B. Choi, B. J.-F. Wong, C.-P. Richter, G. J. Tearney, A. Nuttal, & N. Kollias (Eds.), Photonic Therapeutics and Diagnostics XI Article 93032F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9303). SPIE. https://doi.org/10.1117/12.2077775

O'Brien, Christine M. ; Vargis, Elizabeth ; Slaughter, Chris et al. / Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy. Photonic Therapeutics and Diagnostics XI. editor / Hyun Wook Kang ; Justus F. Ilgner ; Melissa C. Skala ; Laura Marcu ; Haishan Zeng ; Mark W. Dewhirst ; Kenton W. Gregory ; Andreas Mandelis ; Bernard Choi ; Brian Jet-Fei Wong ; Claus-Peter Richter ; Guillermo J. Tearney ; Alfred Nuttal ; Nikiforos Kollias. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

@inproceedings{e4d3f3a16b5f4bde8369bacb76932da8,

title = "Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy",

abstract = "Globally, fifteen million babies are born preterm each year, affecting 1 in 8 pregnancies in the US alone. Cervical remodeling includes a biochemical cascade of changes that ultimately result in the thinning and dilation of the cervix for passage of a fetus. This process is poorly understood and is the focus of this study. Our group is utilizing Raman spectroscopy to evaluate biochemical changes occurring in the human cervix throughout pregnancy. This technique has high molecular specificity and can be performed in vivo, with the potential to unveil new molecular dynamics essential for cervical remodeling.",

keywords = "Cervix, In vivo, Pregnancy, Raman spectroscopy, Remodeling",

author = "O'Brien, \{Christine M.\} and Elizabeth Vargis and Chris Slaughter and Rudin, \{Amy P.\} and Herington, \{Jennifer L.\} and Bennett, \{Kelly A.\} and Jeff Reese and Anita Mahadevan-Jansen",

year = "2015",

doi = "10.1117/12.2077775",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Kang, \{Hyun Wook\} and Ilgner, \{Justus F.\} and Skala, \{Melissa C.\} and Laura Marcu and Haishan Zeng and Dewhirst, \{Mark W.\} and Gregory, \{Kenton W.\} and Andreas Mandelis and Bernard Choi and Wong, \{Brian Jet-Fei\} and Claus-Peter Richter and Tearney, \{Guillermo J.\} and Alfred Nuttal and Nikiforos Kollias",

booktitle = "Photonic Therapeutics and Diagnostics XI",

note = "Photonic Therapeutics and Diagnostics XI ; Conference date: 07-02-2015 Through 08-02-2015",

}

O'Brien, CM, Vargis, E, Slaughter, C, Rudin, AP, Herington, JL, Bennett, KA, Reese, J & Mahadevan-Jansen, A 2015, Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy. in HW Kang, JF Ilgner, MC Skala, L Marcu, H Zeng, MW Dewhirst, KW Gregory, A Mandelis, B Choi, BJ-F Wong, C-P Richter, GJ Tearney, A Nuttal & N Kollias (eds), Photonic Therapeutics and Diagnostics XI., 93032F, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9303, SPIE, Photonic Therapeutics and Diagnostics XI, San Francisco, United States, 02/7/15. https://doi.org/10.1117/12.2077775

Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy. / O'Brien, Christine M.; Vargis, Elizabeth; Slaughter, Chris et al.
Photonic Therapeutics and Diagnostics XI. ed. / Hyun Wook Kang; Justus F. Ilgner; Melissa C. Skala; Laura Marcu; Haishan Zeng; Mark W. Dewhirst; Kenton W. Gregory; Andreas Mandelis; Bernard Choi; Brian Jet-Fei Wong; Claus-Peter Richter; Guillermo J. Tearney; Alfred Nuttal; Nikiforos Kollias. SPIE, 2015. 93032F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9303).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy

AU - O'Brien, Christine M.

AU - Vargis, Elizabeth

AU - Slaughter, Chris

AU - Rudin, Amy P.

AU - Herington, Jennifer L.

AU - Bennett, Kelly A.

AU - Reese, Jeff

AU - Mahadevan-Jansen, Anita

PY - 2015

Y1 - 2015

N2 - Globally, fifteen million babies are born preterm each year, affecting 1 in 8 pregnancies in the US alone. Cervical remodeling includes a biochemical cascade of changes that ultimately result in the thinning and dilation of the cervix for passage of a fetus. This process is poorly understood and is the focus of this study. Our group is utilizing Raman spectroscopy to evaluate biochemical changes occurring in the human cervix throughout pregnancy. This technique has high molecular specificity and can be performed in vivo, with the potential to unveil new molecular dynamics essential for cervical remodeling.

AB - Globally, fifteen million babies are born preterm each year, affecting 1 in 8 pregnancies in the US alone. Cervical remodeling includes a biochemical cascade of changes that ultimately result in the thinning and dilation of the cervix for passage of a fetus. This process is poorly understood and is the focus of this study. Our group is utilizing Raman spectroscopy to evaluate biochemical changes occurring in the human cervix throughout pregnancy. This technique has high molecular specificity and can be performed in vivo, with the potential to unveil new molecular dynamics essential for cervical remodeling.

KW - Cervix

KW - In vivo

KW - Pregnancy

KW - Raman spectroscopy

KW - Remodeling

UR - https://www.scopus.com/pages/publications/84926626309

U2 - 10.1117/12.2077775

DO - 10.1117/12.2077775

M3 - Conference contribution

AN - SCOPUS:84926626309

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photonic Therapeutics and Diagnostics XI

A2 - Kang, Hyun Wook

A2 - Ilgner, Justus F.

A2 - Skala, Melissa C.

A2 - Marcu, Laura

A2 - Zeng, Haishan

A2 - Dewhirst, Mark W.

A2 - Gregory, Kenton W.

A2 - Mandelis, Andreas

A2 - Choi, Bernard

A2 - Wong, Brian Jet-Fei

A2 - Richter, Claus-Peter

A2 - Tearney, Guillermo J.

A2 - Nuttal, Alfred

A2 - Kollias, Nikiforos

PB - SPIE

T2 - Photonic Therapeutics and Diagnostics XI

Y2 - 7 February 2015 through 8 February 2015

ER -

O'Brien CM, Vargis E, Slaughter C, Rudin AP, Herington JL, Bennett KA et al. Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy. In Kang HW, Ilgner JF, Skala MC, Marcu L, Zeng H, Dewhirst MW, Gregory KW, Mandelis A, Choi B, Wong BJF, Richter CP, Tearney GJ, Nuttal A, Kollias N, editors, Photonic Therapeutics and Diagnostics XI. SPIE. 2015. 93032F. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2077775

Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy

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Keywords

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