Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy

Christine M. O'Brien, Elizabeth Vargis, Chris Slaughter, Amy P. Rudin, Jennifer L. Herington, Kelly A. Bennett, Jeff Reese, Anita Mahadevan-Jansen

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations


Globally, fifteen million babies are born preterm each year, affecting 1 in 8 pregnancies in the US alone. Cervical remodeling includes a biochemical cascade of changes that ultimately result in the thinning and dilation of the cervix for passage of a fetus. This process is poorly understood and is the focus of this study. Our group is utilizing Raman spectroscopy to evaluate biochemical changes occurring in the human cervix throughout pregnancy. This technique has high molecular specificity and can be performed in vivo, with the potential to unveil new molecular dynamics essential for cervical remodeling.

Original languageEnglish
Title of host publicationPhotonic Therapeutics and Diagnostics XI
EditorsHyun Wook Kang, Justus F. Ilgner, Melissa C. Skala, Laura Marcu, Haishan Zeng, Mark W. Dewhirst, Kenton W. Gregory, Andreas Mandelis, Bernard Choi, Brian Jet-Fei Wong, Claus-Peter Richter, Guillermo J. Tearney, Alfred Nuttal, Nikiforos Kollias
ISBN (Electronic)9781628413939
StatePublished - 2015
EventPhotonic Therapeutics and Diagnostics XI - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotonic Therapeutics and Diagnostics XI
Country/TerritoryUnited States
CitySan Francisco


  • Cervix
  • In vivo
  • Pregnancy
  • Raman spectroscopy
  • Remodeling


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