@article{4548352df18c45f6a538ac69ec3885d6,
title = "Characterization of Glomerular and Tubulointerstitial Proteomes in a Case of Nonsteroidal Anti-Inflammatory Drug–Attributed Acute Kidney Injury A Clinical Pathologic Molecular Correlation",
abstract = "The major goals of the Kidney Precision Medicine Project (KPMPP) are to establish a molecular atlas of the kidney in health and disease and improve our understanding of the molecular drivers of CKD and AKI. In this clinical-pathologic-molecular correlation, we describe the case of a 38-year-old woman without any history of CKD who underwent a research kidney biopsy in the setting of AKI suspected to be due to nonsteroidal anti-inflammatory use after cesarean section delivery. The participant{\textquoteright}s histopathology was consistent with mild acute tubular injury, without significant interstitial fibrosis or tubular atrophy. This diagnosis was supported by analysis of the glomerular and tubulointerstitial proteomes. The proteomic interrogation revealed a molecular landscape that demonstrated differences in kidney prostaglandin synthesis that may be in response to nonsteroidal antiinflammatory drugs and signs of intrarenal inflammation and fibrosis that were not evident by histopathology alone.",
author = "{the Kidney Precision Medicine Project} and Parikh, {Samir V.} and Sethu Madhavan and John Shapiro and Richard Knight and Rosenberg, {Avi Z.} and Parikh, {Chirag R.} and Brad Rovin and Steven Menez and Richard Knight and Lecker, {Stewart H.} and Isaac Stillman and Steve Bogen and Beck, {Laurence H.} and Sushrut Waikar and McMahon, {Gearoid M.} and Astrid Weins and Colona, {Mia R.} and Nir Hacohen and Hoover, {Paul J.} and Mark Aulisio and Bush, {William S.} and Crawford, {Dana C.} and John O{\textquoteright}Toole and Emilio Poggio and John Sedor and Leslie Cooperman and Stacey Jolly and Leal Herlitz and Jane Nguyen and Agustin Gonzalez-Vicente and Ellen Palmer and Dianna Sendrey and Carissa Vi-Novskis and Bjornstad, {Petter M.} and Paul Appelbaum and Bar-Asch, {Jonathan M.} and Bomback, {Andrew S.} and D{\textquoteright}Agati, {Vivette D.} and Krzysztof Kiryluk and Karla Mehl and Canetta, {Pietro A.} and Ning Shang and Olivia Balderes and Satoru Kudose and Shweta Bansal and Theodore Alexandrov and Helmut Rennke and El-Achkar, {Tarek M.} and Yinghua Cheng and Dagher, {Pierre C.} and Eadon, {Michael T.} and Dunn, {Kenneth W.} and Kelly, {Katherine J.} and Sutton, {Timothy A.} and Daria Barwinska and Ferkowicz, {Michael J.} and Seth Winfree and Sharon Bledsoe and Marcelino Rivera and Williams, {James C.} and Ferreira, {Ricardo Melo} and Parikh, {Chirag R.} and {Corona Villalobos}, {Celia P.} and Steven Menez and Avi Rosenberg and Rosas, {Sylvia E.} and Neil Roy and Mark Williams and Azeloglu, {Evren U.} and Cijang He and Ravi Iyengar and Jens Hansen and Yuguang Xiong and Brad Rovin and Samir Parikh and Shapiro, {John P.} and Anderton, {Christopher R.} and Ljiljana PasaTolic and Dusan Velickovic and Jessica Lukowski and George Oliver and Joseph Ardayfio and Jack Bebiak and Keith Brown and Campbell, {Catherine E.} and John Saul and Anna Shpigel and Christy Stutzke and Robert Koewler and Taneisha Campbell and Lynda Hayashi and Nichole Jefferson and Roberts, {Glenda V.} and Roy Pinkeney and Olga Troyanskaya and Rachel Sealfon and Tuttle, {Katherine R.} and Yury Goltsev and Kun Zhang and Lake, {Blue B.} and Laszik, {Zoltan G.} and Garry Nolan and Patrick Boada and Minnie Sarwal and Tara Sigdel and Lee, {Paul J.} and Alloway, {Rita R.} and Steve Woodle and Heather Ascani and Balis, {Ulysses G.J.} and Hodgin, {Jeffrey B.} and Matthias Kretzler and Chrysta Lienczewski and Mariani, {Laura H.} and Rajasree Menon and Becky Steck and Yougqun He and Edgar Otto and Jennifer Schaub and Blanc, {Victoria M.} and Sean Eddy and Conser, {Ninive C.} and Jinghui Luo and Palevsky, {Paul M.} and Matthew Rosengart and Kellum, {John A.} and Hall, {Daniel E.} and Parmjeet Randhawa and Mitchell Tublin and Raghavan Murugan and Elder, {Michele M.} and James Winters and Alpers, {Charles E.} and Blank, {Kristina N.} and Jonas Carson and {De Boer}, {Ian H.} and Dighe, {Ashveena L.} and Jonathan Himmelfarb and Mooney, {Sean D.} and Stuart Shankland and Kayleen Williams and Christopher Park and Frederick Dowd and McClelland, {Robyn L.} and Stephen Daniel and Hoofnagle, {Andrew N.} and Adam Wilcox and Grewenow, {Stephanie M.} and Kumar Sharma and Manjeri Venkatachalam and Guanshi Zhang and Annapurna Pamreddy and Hongping Ye and Richard Montellano and Toto, {Robert D.} and Miguel Vazquez and Lee, {Simon C.} and Miller, {R. Tyler} and Moe, {Orson W.} and Jose Torrealba and Nancy Wang and Asra Kermani and Kamalanathan Sambandam and Harold Park and Hedayati, {S. Susan} and Lu, {Christopher Y.} and Sanjay Jain and Anitha Vijayan and Gaut, {Joseph P.} and Dennis Moledina and Wilson, {Francis P.} and Ugochukwu Ugwuowo and Tanima Arora",
note = "Publisher Copyright: Copyright {\textcopyright} 2022 by the American Society of Nephrology.",
year = "2023",
month = mar,
doi = "10.2215/CJN.09260822",
language = "English",
volume = "18",
pages = "402--410",
journal = "Clinical Journal of the American Society of Nephrology",
issn = "1555-9041",
number = "3",
}